Please use this identifier to cite or link to this item: https://doi.org/10.1002/jssc.200900831
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dc.titleThe impact of silica gel pore and particle sizes on HPLC column efficiency and resolution for an immobilized, cyclodextrinbased, chiral stationary phase
dc.contributor.authorQin, Q.
dc.contributor.authorZhang, S.
dc.contributor.authorZhang, W.-G.
dc.contributor.authorZhang, Z.-B.
dc.contributor.authorXiong, Y.-J.
dc.contributor.authorGuo, Z.-Y.
dc.contributor.authorFan, J.
dc.contributor.authorRun-Zheng, S.
dc.contributor.authorFinlow, D.
dc.contributor.authorYin, Y.
dc.date.accessioned2014-10-16T08:45:25Z
dc.date.available2014-10-16T08:45:25Z
dc.date.issued2010-09
dc.identifier.citationQin, Q., Zhang, S., Zhang, W.-G., Zhang, Z.-B., Xiong, Y.-J., Guo, Z.-Y., Fan, J., Run-Zheng, S., Finlow, D., Yin, Y. (2010-09). The impact of silica gel pore and particle sizes on HPLC column efficiency and resolution for an immobilized, cyclodextrinbased, chiral stationary phase. Journal of Separation Science 33 (17-18) : 2582-2589. ScholarBank@NUS Repository. https://doi.org/10.1002/jssc.200900831
dc.identifier.issn16159306
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95237
dc.description.abstractIn this study, the CD derivative, mono (6A-azido-6 A-deoxy)-per(p-chlorophenylcarbamonylated) β-CD was chemically immobilized onto the surface of an aminofunctionalized silica gel with different pore (100, 300, and 500Å) and particle (3, 5, and 10 mm) sizes to obtain novel chiral stationary phases. The impact of pore and particle size on the amount of immobilized Ph-b-CD, column performance, and enantioselectivity was investigated by evaluating the separation of a variety of racemates in both the normal- and the reversed-phase modes. Experimental results revealed that the retention factor and resolution of racemates generally decreased with increasing pore size; the column prepared with the smallest (3 μm) silica gel particle size gave the best column performance and enantioselectivity in both the normal- and the reversed-phase modes. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jssc.200900831
dc.sourceScopus
dc.subjectCD
dc.subjectChiral stationary phase
dc.subjectHPLC
dc.subjectParticle size
dc.subjectPore size
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1002/jssc.200900831
dc.description.sourcetitleJournal of Separation Science
dc.description.volume33
dc.description.issue17-18
dc.description.page2582-2589
dc.description.codenJSSCC
dc.identifier.isiut000282612900005
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