Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ica.2009.12.047
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dc.titleSynthesis, crystal structures, DNA-binding properties, cytotoxic and antioxidation activities of several new ternary copper(II) complexes of N,N′-(p-xylylene)di-alanine acid and 1,10-phenanthroline
dc.contributor.authorJia, L.
dc.contributor.authorJiang, P.
dc.contributor.authorXu, J.
dc.contributor.authorHao, Z.-y.
dc.contributor.authorXu, X.-m.
dc.contributor.authorChen, L.-h.
dc.contributor.authorWu, J.-c.
dc.contributor.authorTang, N.
dc.contributor.authorWang, Q.
dc.contributor.authorVittal, J.J.
dc.date.accessioned2014-10-16T08:44:31Z
dc.date.available2014-10-16T08:44:31Z
dc.date.issued2010-03-22
dc.identifier.citationJia, L., Jiang, P., Xu, J., Hao, Z.-y., Xu, X.-m., Chen, L.-h., Wu, J.-c., Tang, N., Wang, Q., Vittal, J.J. (2010-03-22). Synthesis, crystal structures, DNA-binding properties, cytotoxic and antioxidation activities of several new ternary copper(II) complexes of N,N′-(p-xylylene)di-alanine acid and 1,10-phenanthroline. Inorganica Chimica Acta 363 (5) : 855-865. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ica.2009.12.047
dc.identifier.issn00201693
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95159
dc.description.abstractThree novel ternary copper(II) complexes, [Cu2(phen)2(l-PDIAla)(H2O)2](ClO4)2·2.5H2O (1), [Cu4(phen)6(d,l-PDIAla)(H2O)2](ClO4)6·3H2O (2) and [Cu2(phen)2(d,l-PDIAla)(H2O)](ClO4)2·0.5H2O (3) (phen = 1,10-phenanthroline, H2PDIAla = N,N'-(p-xylylene)di-alanine acid) have been synthesized and structurally characterized by single-crystal X-ray crystallography and other structural analysis. Spectrometric titrations, ethidium bromide displacement experiments, CD (circular dichroism) spectral analysis and viscosity measurements indicate that the three compounds, especially the complex 3, strongly bind to calf-thymus DNA (CT-DNA). The intrinsic binding constants of the ternary copper(II) complexes with CT-DNA are 0.89 × 105, 1.14 × 105 and 1.72 × 105 M-1, for 1, 2 and 3, respectively. Comparative cytotoxic activities of the copper(II) complexes are also determined by acid phosphatase assay. The results show that the ternary copper(II) complexes have significant cytotoxic activity against the HeLa (Cervical cancer), HepG2 (hepatocarcinoma), HL-60 cells (myeloid leukemia), A-549 cells (pulmonary carcinoma) and L02 (liver cells). Investigations of antioxidation properties show that all the copper(II) complexes have strong scavenging effects for hydroxyl radicals and superoxide radicals. © 2009 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ica.2009.12.047
dc.sourceScopus
dc.subjectCytotoxicity
dc.subjectDNA-binding properties
dc.subjectPhenanthroline base
dc.subjectReduce Schiff base
dc.subjectTernary copper(II) complexes
dc.subjectX-ray crystallography
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.ica.2009.12.047
dc.description.sourcetitleInorganica Chimica Acta
dc.description.volume363
dc.description.issue5
dc.description.page855-865
dc.description.codenICHAA
dc.identifier.isiut000275233500004
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