Please use this identifier to cite or link to this item:
https://doi.org/10.1002/anie.201307757
DC Field | Value | |
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dc.title | Phosphine-catalyzed enantioselective γ-addition of 3-substituted oxindoles to 2,3-butadienoates and 2-butynoates: Use of prochiral nucleophiles | |
dc.contributor.author | Wang, T. | |
dc.contributor.author | Yao, W. | |
dc.contributor.author | Zhong, F. | |
dc.contributor.author | Pang, G.H. | |
dc.contributor.author | Lu, Y. | |
dc.date.accessioned | 2014-10-16T08:36:53Z | |
dc.date.available | 2014-10-16T08:36:53Z | |
dc.date.issued | 2014-03-10 | |
dc.identifier.citation | Wang, T., Yao, W., Zhong, F., Pang, G.H., Lu, Y. (2014-03-10). Phosphine-catalyzed enantioselective γ-addition of 3-substituted oxindoles to 2,3-butadienoates and 2-butynoates: Use of prochiral nucleophiles. Angewandte Chemie - International Edition 53 (11) : 2964-2968. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201307757 | |
dc.identifier.issn | 14337851 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/94509 | |
dc.description.abstract | The first phosphine-catalyzed enantioselective γ-addition with prochiral nucleophiles and 2,3-butadienoates as the reaction partners has been developed. Both 3-alkyl- and 3-aryl-substituted oxindoles could be employed in this process, which is catalyzed by a chiral phosphine that is derived from an amino acid, thus affording oxindoles that bear an all-carbon quaternary center at the 3-position in high yields and excellent enantioselectivity. The synthetic value of these γ-addition products was demonstrated by the formal total synthesis of two natural products and by the preparation of biologically relevant molecules and structural scaffolds. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.201307757 | |
dc.source | Scopus | |
dc.subject | γ-addition | |
dc.subject | allylation | |
dc.subject | bifunctional phosphines | |
dc.subject | oxindoles | |
dc.subject | quaternary carbon centers | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1002/anie.201307757 | |
dc.description.sourcetitle | Angewandte Chemie - International Edition | |
dc.description.volume | 53 | |
dc.description.issue | 11 | |
dc.description.page | 2964-2968 | |
dc.description.coden | ACIEF | |
dc.identifier.isiut | 000336846300016 | |
Appears in Collections: | Staff Publications |
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