Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jcat.2012.05.007
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dc.titleN-alkylation of amines with alcohols over alumina-entrapped Ag catalysts using the "borrowing hydrogen" methodology
dc.contributor.authorLiu, H.
dc.contributor.authorChuah, G.-K.
dc.contributor.authorJaenicke, S.
dc.date.accessioned2014-10-16T08:34:53Z
dc.date.available2014-10-16T08:34:53Z
dc.date.issued2012-08
dc.identifier.citationLiu, H., Chuah, G.-K., Jaenicke, S. (2012-08). N-alkylation of amines with alcohols over alumina-entrapped Ag catalysts using the "borrowing hydrogen" methodology. Journal of Catalysis 292 : 130-137. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jcat.2012.05.007
dc.identifier.issn00219517
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/94342
dc.description.abstractAg/Al 2O 3 catalysts were found to be highly active and selective in the N-alkylation of aniline with a variety of aromatic and linear alcohols. In the presence of a base, for example, Cs 2CO 3 or K 3PO 4 as promoter, high yields of secondary amines were obtained. The highest activity was found with 2.4 wt.% Ag/Al 2O 3. The reaction involves the transient catalytic dehydrogenation of the alkylating alcohol to the corresponding carbonyl compound which then reacts spontaneously with the amine. In the final step, the hydrogen from the alcohol dehydrogenation step is transferred back to the imine, giving the secondary amine as the final product. With secondary amines, piperidine and pyrrolidine, the hemiaminal intermediate can undergo dehydrogenation as well as dehydration to give amides and amines, respectively. The heterogeneous nature of Ag/Al 2O 3 allows for easy recovery and regeneration, which makes it an attractive system in the context of green and sustainable synthesis. © 2012 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jcat.2012.05.007
dc.sourceScopus
dc.subjectAlcohol
dc.subjectAmide
dc.subjectAmine
dc.subjectBorrowing hydrogen
dc.subjectHeterogeneous catalysis
dc.subjectN-alkylation
dc.subjectSilver
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.jcat.2012.05.007
dc.description.sourcetitleJournal of Catalysis
dc.description.volume292
dc.description.page130-137
dc.description.codenJCTLA
dc.identifier.isiut000307091200014
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