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Title: Hormesis of Glyceollin I, an induced Phytoalexin from Soybean, on budding yeast chronological lifespan extension
Authors: Liu, Y.
Wu, Z.
Feng, S.
Yang, X.
Huang, D. 
Keywords: Aging
Chronological life span
Glyceollin I
Induced phytoalexin
Issue Date: Jan-2014
Citation: Liu, Y., Wu, Z., Feng, S., Yang, X., Huang, D. (2014-01). Hormesis of Glyceollin I, an induced Phytoalexin from Soybean, on budding yeast chronological lifespan extension. Molecules 19 (1) : 568-580. ScholarBank@NUS Repository.
Abstract: Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, antiestrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular contractions. Here we show that glyceollin I has hormesis and extends yeast life span at low (nM) doses in a calorie restriction (CR)-dependent manner, while it reduces life span and inhibits yeast cell proliferation at higher (μM) doses. In contrast, the other two isomers (glyceollin II and III) cannot extend yeast life span and only show life span reduction and antiproliferation at higher doses. Our results in anti-Aging activity indicate that glyceollin I might be a promising calorie restriction mimetic candidate, and the high content of glyceollins could improve the bioactivity of soybean as functional food ingredients.© 2014 by the authors licensee MDPI Basel Switzerland.
Source Title: Molecules
ISSN: 14203049
DOI: 10.3390/molecules19010568
Appears in Collections:Staff Publications

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