Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.10545
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dc.titleFlexible chitin films as potential wound-dressing materials: Wound model studies
dc.contributor.authorYusof, N.L.B.M.
dc.contributor.authorWee, A.
dc.contributor.authorLim, L.Y.
dc.contributor.authorKhor, E.
dc.date.accessioned2014-10-16T08:28:47Z
dc.date.available2014-10-16T08:28:47Z
dc.date.issued2003-08-01
dc.identifier.citationYusof, N.L.B.M., Wee, A., Lim, L.Y., Khor, E. (2003-08-01). Flexible chitin films as potential wound-dressing materials: Wound model studies. Journal of Biomedical Materials Research - Part A 66 (2) : 224-232. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.10545
dc.identifier.issn00219304
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/93820
dc.description.abstractChitin films possessing increased flexibility, softness, transparency, and conformability have been prepared. These attributes enable the potential application of chitin films as occlusive, semipermeable film wound dressings similar to commercial products such as Opsite™. The chitin films are generally nonabsorbent, exhibiting a total weight gain of only up to 120-160% in physiological fluid. Dry chitin films transpire water vapor at a rate of about 600 g/m2/24 h, similar to commercial polyurethane-based film dressings, but rises to 2400 g/m2/24 h, when wet, which is higher than the water vapor transmission rate of intact skin. The chitin films are nontoxic to human skin fibroblasts, maintaining 70-80% cell viability. Wound studies using a rat model showed no signs of allergenicity or the high inflammatory response associated with biodegradable biomaterials. The chitin films displayed accelerated wound-healing properties. Based on histological examination, wound sites dressed with the chitin films stabilized and healed faster, and appeared stronger than those dressed with Opsite™ and gauze dressings after 7 days of healing. © 2003 Wiley Periodicals, Inc.
dc.sourceScopus
dc.subjectChitin film
dc.subjectCytotoxicity
dc.subjectWater vapor transmission rate
dc.subjectWound dressings
dc.subjectWound healing
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.contributor.departmentPHARMACY
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1002/jbm.a.10545
dc.description.sourcetitleJournal of Biomedical Materials Research - Part A
dc.description.volume66
dc.description.issue2
dc.description.page224-232
dc.description.codenJBMRC
dc.identifier.isiutNOT_IN_WOS
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