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Title: Chemical and biological studies of gold(III) complexes with uninegative bidentate N-N ligands
Authors: Fan, D.
Yang, C.-T. 
Ranford, J.D. 
Vittal, J.J. 
Issue Date: 21-Dec-2003
Citation: Fan, D.,Yang, C.-T.,Ranford, J.D.,Vittal, J.J. (2003-12-21). Chemical and biological studies of gold(III) complexes with uninegative bidentate N-N ligands. Dalton Transactions (24) : 4749-4753. ScholarBank@NUS Repository.
Abstract: Three new gold(III) complexes with uninegative bidentate N-N ligands ([Au(pla)Cl2] (1), Hpla = picolinamide; [{Au(pz)Cl2}2] (2), Hpz = pyrazole; [{Au(mpz)Cl2}2] (3), Hmpz = 3-methylpyrazole) have been synthesized and characterized spectroscopically. The crystal structure of 1 contains one five-membered chelated ring and two cis-oriented chloride anions. It is the closest Au(III) analogue to cisplatin with an N-H group in the molecule and it forms a hydrogen bond with the carbonyl from adjacent molecule. The crystal structure of 2 shows a symmetrical six-membered Au(N-N)2Au ring. The two N-N bridging bonds and two gold atoms adopt a boat conformation, a configuration which thermodynamically stabilizes the complex. The two gold centres are square planar, each coordinated by two cis-oriented chlorides and nitrogens, respectively. These three new complexes have been tested for cytotoxic properties in vitro against MOLT-4 (human leukemia) and C2C12 (mouse tumour) cell lines. The results show that these complexes are slightly more cytotoxic than the clinically used cisplatin.
Source Title: Dalton Transactions
ISSN: 14779226
Appears in Collections:Staff Publications

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