Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/92147
DC Field | Value | |
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dc.title | Monochloro-substituted phenyl carbamoylated β-cyclodextrins as π-acid chiral stationary phases for high-performance liquid chromatography | |
dc.contributor.author | Bai, Z.W. | |
dc.contributor.author | Ching, C.B. | |
dc.contributor.author | Ng, S.C. | |
dc.date.accessioned | 2014-10-09T09:56:47Z | |
dc.date.available | 2014-10-09T09:56:47Z | |
dc.date.issued | 2003-07 | |
dc.identifier.citation | Bai, Z.W.,Ching, C.B.,Ng, S.C. (2003-07). Monochloro-substituted phenyl carbamoylated β-cyclodextrins as π-acid chiral stationary phases for high-performance liquid chromatography. Chromatographia 58 (1-2) : 43-46. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00095893 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/92147 | |
dc.description.abstract | Three π-acid type chiral stationary phases based on monochloro-substituted phenyl carbamates of β-cyclodextrin have been synthesized. First, β-cyclodextrin was reacted with 5-bromo-1-pentene in dry DMF at room temperature to give 6A-O-(4′-pentenyl)-β-cyclodextrin. The remaining twenty hydroxyl groups of this derivatized β-cyclodextrin were blocked by further reaction with 2-chlorophenyl isocyanate, 3-chlorophenyl isocyanate, and 4-chlorophenyl isocyanate in dry pyridine, at 85°C, to yield the three corresponding carbamates. After hydrosilylation with triethoxysilane at 80°C, catalysed by tetra(triphenylphosphine)platinum(0), these carbamates were anchored on to silica gel by heating under reflux in toluene. All the β-cyclodextrin derivatives and CSPs prepared were characterized by IR and 1H NMR spectroscopy and elemental analysis. The surface concentrations of 2-chlorophenyl carbamoylated β-cyclodextrin, 3-chlorophenyl carbamoylated β-cyclodextrin, and 4-chlorophenyl carbamoylated β-cyclodextrin on silica gel were 0.27, 0.28 ond 0.30 μmol m-2, respectively. Under normal-phase conditions the separation ability of CSPs containing 3- and 4-chlorophenyl carbamate was better than that of the CSPs containing 2-chlorophenyl carbamate. | |
dc.source | Scopus | |
dc.subject | β-Cyclodextrin | |
dc.subject | Chiral stationary phase | |
dc.subject | Column liquid chromatography | |
dc.subject | Enantioseparation | |
dc.subject | Monochloro-substituted phenyl carbamate | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.department | CHEMICAL & ENVIRONMENTAL ENGINEERING | |
dc.description.sourcetitle | Chromatographia | |
dc.description.volume | 58 | |
dc.description.issue | 1-2 | |
dc.description.page | 43-46 | |
dc.description.coden | CHRGB | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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