Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.talanta.2013.03.072
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dc.titleSimultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution
dc.contributor.authorTran, N.H.
dc.contributor.authorHu, J.
dc.contributor.authorOng, S.L.
dc.date.accessioned2014-10-09T07:39:27Z
dc.date.available2014-10-09T07:39:27Z
dc.date.issued2013
dc.identifier.citationTran, N.H., Hu, J., Ong, S.L. (2013). Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution. Talanta 113 : 82-92. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2013.03.072
dc.identifier.issn00399140
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/91220
dc.description.abstractA high-throughput method for the simultaneous determination of 24 pharmaceuticals and personal care products (PPCPs), endocrine disrupting chemicals (EDCs) and artificial sweeteners (ASs) was developed. The method was based on a single-step solid phase extraction (SPE) coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and isotope dilution. In this study, a single-step SPE procedure was optimized for simultaneous extraction of all target analytes. Good recoveries (≥70%) were observed for all target analytes when extraction was performed using Chromabond® HR-X (500 mg, 6 mL) cartridges under acidic condition (pH 2). HPLC-MS/MS parameters were optimized for the simultaneous analysis of 24 PPCPs, EDCs and ASs in a single injection. Quantification was performed by using 13 isotopically labeled internal standards (ILIS), which allows correcting efficiently the loss of the analytes during SPE procedure, matrix effects during HPLC-MS/MS and fluctuation in MS/MS signal intensity due to instrument. Method quantification limit (MQL) for most of the target analytes was below 10 ng/L in all water samples. The method was successfully applied for the simultaneous determination of PPCPs, EDCs and ASs in raw wastewater, surface water and groundwater samples collected in a local catchment area in Singapore. In conclusion, the developed method provided a valuable tool for investigating the occurrence, behavior, transport, and the fate of PPCPs, EDCs and ASs in the aquatic environment. © 2013 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.talanta.2013.03.072
dc.sourceScopus
dc.subjectArtificial sweeteners
dc.subjectEndocrine disrupting chemicals
dc.subjectHigh performance liquid chromatography-tandem mass spectrometry
dc.subjectPharmaceuticals and personal care products
dc.subjectSimultaneous determination
dc.subjectSolid-phase extraction (SPE)
dc.typeArticle
dc.contributor.departmentCIVIL & ENVIRONMENTAL ENGINEERING
dc.description.doi10.1016/j.talanta.2013.03.072
dc.description.sourcetitleTalanta
dc.description.volume113
dc.description.page82-92
dc.description.codenTLNTA
dc.identifier.isiut000320416500013
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