Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.talanta.2013.03.072
DC Field | Value | |
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dc.title | Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution | |
dc.contributor.author | Tran, N.H. | |
dc.contributor.author | Hu, J. | |
dc.contributor.author | Ong, S.L. | |
dc.date.accessioned | 2014-10-09T07:39:27Z | |
dc.date.available | 2014-10-09T07:39:27Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Tran, N.H., Hu, J., Ong, S.L. (2013). Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution. Talanta 113 : 82-92. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2013.03.072 | |
dc.identifier.issn | 00399140 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/91220 | |
dc.description.abstract | A high-throughput method for the simultaneous determination of 24 pharmaceuticals and personal care products (PPCPs), endocrine disrupting chemicals (EDCs) and artificial sweeteners (ASs) was developed. The method was based on a single-step solid phase extraction (SPE) coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and isotope dilution. In this study, a single-step SPE procedure was optimized for simultaneous extraction of all target analytes. Good recoveries (≥70%) were observed for all target analytes when extraction was performed using Chromabond® HR-X (500 mg, 6 mL) cartridges under acidic condition (pH 2). HPLC-MS/MS parameters were optimized for the simultaneous analysis of 24 PPCPs, EDCs and ASs in a single injection. Quantification was performed by using 13 isotopically labeled internal standards (ILIS), which allows correcting efficiently the loss of the analytes during SPE procedure, matrix effects during HPLC-MS/MS and fluctuation in MS/MS signal intensity due to instrument. Method quantification limit (MQL) for most of the target analytes was below 10 ng/L in all water samples. The method was successfully applied for the simultaneous determination of PPCPs, EDCs and ASs in raw wastewater, surface water and groundwater samples collected in a local catchment area in Singapore. In conclusion, the developed method provided a valuable tool for investigating the occurrence, behavior, transport, and the fate of PPCPs, EDCs and ASs in the aquatic environment. © 2013 Elsevier B.V. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.talanta.2013.03.072 | |
dc.source | Scopus | |
dc.subject | Artificial sweeteners | |
dc.subject | Endocrine disrupting chemicals | |
dc.subject | High performance liquid chromatography-tandem mass spectrometry | |
dc.subject | Pharmaceuticals and personal care products | |
dc.subject | Simultaneous determination | |
dc.subject | Solid-phase extraction (SPE) | |
dc.type | Article | |
dc.contributor.department | CIVIL & ENVIRONMENTAL ENGINEERING | |
dc.description.doi | 10.1016/j.talanta.2013.03.072 | |
dc.description.sourcetitle | Talanta | |
dc.description.volume | 113 | |
dc.description.page | 82-92 | |
dc.description.coden | TLNTA | |
dc.identifier.isiut | 000320416500013 | |
Appears in Collections: | Staff Publications |
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