Monitoring the hydrolysis of acetic anhydride using in-situ Raman spectroscopy and novel multivariate data analysis - Band-Target Entropy Minimization (BTEM)

Abstract

With the increasing demand for novel process analytical technologies in recent years, Raman spectroscopy has been one of the powerful choices for in-situ reaction monitoring. In this paper, we discuss the use of in-situ Raman spectroscopy and novel multivariate data analysis method namely band-target entropy minimization (BTEM) to monitor the hydrolysis of acetic anhydride to acetic acid. In-situ Raman spectroscopy is employed to continuously measure the spectrum of reaction mixture for a few hours time. The collected reaction spectra are then subjected to BTEM in order to elucidate the pure component spectra and the concentration profiles of the observed components. In addition, a comparison study between univariate and multivariate data analysis on the reaction spectra is also presented.