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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2008.11.078
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dc.titleSynthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones
dc.contributor.authorMa, X.
dc.contributor.authorZhou, W.
dc.contributor.authorBrun, R.
dc.date.accessioned2014-10-09T07:03:35Z
dc.date.available2014-10-09T07:03:35Z
dc.date.issued2009-02-01
dc.identifier.citationMa, X., Zhou, W., Brun, R. (2009-02-01). Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones. Bioorganic and Medicinal Chemistry Letters 19 (3) : 986-989. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2008.11.078
dc.identifier.issn0960894X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/90291
dc.description.abstractChagas' disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most serious parasitic diseases in Latin America. The currently available chemotherapy, based on nifurtimox or benznidazole, is unsatisfactory due to the limited efficacy in the prevalent chronic stage of the disease and toxic side effects. In order to address these deficiencies, a series of quinolones based novel molecules have been synthesized and evaluated as potential antitrypanosomal agents. The most active analogue 10 inhibited T. cruzi with an IC50 of 1.3 μg/mL. The results of this study have implications in the development of novel quinolone's antitrypanosomal agents. © 2008 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bmcl.2008.11.078
dc.sourceScopus
dc.subjectAntibacterial activity
dc.subjectAntitrypanosomal
dc.subjectChagas' disease
dc.subjectQuinolones
dc.subjectTrypanosoma cruzi
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.bmcl.2008.11.078
dc.description.sourcetitleBioorganic and Medicinal Chemistry Letters
dc.description.volume19
dc.description.issue3
dc.description.page986-989
dc.description.codenBMCLE
dc.identifier.isiut000262707000095
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