Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s10870-011-0147-y
DC Field | Value | |
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dc.title | Structural, spectroscopic and thermal analysis of cocrystals of carbamazepine and piracetam with hydroquinone | |
dc.contributor.author | Aitipamula, S. | |
dc.contributor.author | Chow, P.S. | |
dc.contributor.author | Tan, R.B.H. | |
dc.date.accessioned | 2014-10-09T07:02:42Z | |
dc.date.available | 2014-10-09T07:02:42Z | |
dc.date.issued | 2011-11 | |
dc.identifier.citation | Aitipamula, S., Chow, P.S., Tan, R.B.H. (2011-11). Structural, spectroscopic and thermal analysis of cocrystals of carbamazepine and piracetam with hydroquinone. Journal of Chemical Crystallography 41 (11) : 1604-1611. ScholarBank@NUS Repository. https://doi.org/10.1007/s10870-011-0147-y | |
dc.identifier.issn | 10741542 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/90214 | |
dc.description.abstract | Cocrystals of two important active pharmaceutical ingredients, carbamazepine and piracetam, with hydroquinone are reported. Cocrystal formation between the selected APIs and hydroquinone is investigated with the aid of solid-state grinding methods. Both the crystal structures belong to the triclinic, P 1 space group, with the cocrystal involving carbamazepine and hydroquinone having the unit cell parameters a = 6.9725 (14) Å, b = 8.8175 (18) Å, c = 15.083 (3) Å, α = 106.96 (3)°, β = 92.16 (3)°, γ = 103.23 (3)°, V = 858.0 (4) Å3 and Z = 2; and the cocrystal involving piracetam and hydroquinone has the unit cell parameters a = 6.4909 (13) Å, b = 6.5410 (13) Å, c = 11.612 (2) Å, α = 103.92 (3)°, β = 104.53 (3)°, γ = 91.06 (3)°, V = 461.59 (18) Å3 and Z = 2. Analysis of the cocrystals revealed that they are sustained by an alcohol-carboxamide heterosynthon. In addition, the cocrystal of carbamazepine and hydroquinone features an amide-alcohol heterosynthon and an alcohol-alcohol homosynthon. The cocrystal of piracetam and hydroquinone features an amide-amide dimer synthon. Cocrystal formation was evidenced from the shifts in the vibrational frequencies corresponding to the functional groups present on the cocrystal components. © 2011 Springer Science+Business Media, LLC. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s10870-011-0147-y | |
dc.source | Scopus | |
dc.subject | Carbamazepine | |
dc.subject | Cocrystal | |
dc.subject | Crystal structure | |
dc.subject | Hydroquinone | |
dc.subject | Infrared | |
dc.subject | Piracetam | |
dc.subject | Synthon | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1007/s10870-011-0147-y | |
dc.description.sourcetitle | Journal of Chemical Crystallography | |
dc.description.volume | 41 | |
dc.description.issue | 11 | |
dc.description.page | 1604-1611 | |
dc.identifier.isiut | 000295366000002 | |
Appears in Collections: | Staff Publications |
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