Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2py20837g
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dc.titleSingle molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging
dc.contributor.authorLiu, J.
dc.contributor.authorLi, K.
dc.contributor.authorGeng, J.
dc.contributor.authorZhou, L.
dc.contributor.authorChandrasekharan, P.
dc.contributor.authorYang, C.-T.
dc.contributor.authorLiu, B.
dc.date.accessioned2014-10-09T07:02:05Z
dc.date.available2014-10-09T07:02:05Z
dc.date.issued2013-03-07
dc.identifier.citationLiu, J., Li, K., Geng, J., Zhou, L., Chandrasekharan, P., Yang, C.-T., Liu, B. (2013-03-07). Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging. Polymer Chemistry 4 (5) : 1517-1524. ScholarBank@NUS Repository. https://doi.org/10.1039/c2py20837g
dc.identifier.issn17599954
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/90162
dc.description.abstractWe designed and synthesized a gadolinium(iii)-decorated hyperbranched polyglycerol with a fluorescent polyhedral oligomeric silsesquioxane core (POSS-HPG-Gd), and demonstrated its application as a single-molecular nanoprobe for fluorescence and magnetic resonance dual imaging. The nanoprobe exhibited a uniform size with a mean diameter of 6 ± 1 nm revealed by transmission electron microscopy. POSS-HPG-Gd showed absorption and emission maxima at 405 and 570 nm in water, respectively, with a quantum yield of 41 ± 1%. Fluorescence cell imaging by confocal laser scanning microscopy using MCF-7 cancer cells as a model cell line revealed that the nanoprobe had been successfully internalized into the cytoplasm with high brightness, low cytotoxicity and good photostability. Further magnetic resonance imaging study demonstrated that POSS-HPG-Gd can serve as a promising probe for fluorescence and magnetic resonance dual modal imaging. © 2013 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c2py20837g
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c2py20837g
dc.description.sourcetitlePolymer Chemistry
dc.description.volume4
dc.description.issue5
dc.description.page1517-1524
dc.identifier.isiut000314478800028
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