Please use this identifier to cite or link to this item: https://doi.org/10.1002/aic.11266
DC FieldValue
dc.titleRobust optimal control of polymorphic transformation in batch crystallization
dc.contributor.authorHermanto, M.W.
dc.contributor.authorChiu, M.-S.
dc.contributor.authorWoo, X.-Y.
dc.contributor.authorBraatz, R.D.
dc.date.accessioned2014-10-09T07:00:46Z
dc.date.available2014-10-09T07:00:46Z
dc.date.issued2007-10
dc.identifier.citationHermanto, M.W., Chiu, M.-S., Woo, X.-Y., Braatz, R.D. (2007-10). Robust optimal control of polymorphic transformation in batch crystallization. AIChE Journal 53 (10) : 2643-2650. ScholarBank@NUS Repository. https://doi.org/10.1002/aic.11266
dc.identifier.issn00011541
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/90047
dc.description.abstractOne of the most important problems that can arise in the development of a pharmaceutical crystallization process is the control of polymorphism, in which there exist different crystal forms for the same chemical compound. Different polymorphs can have very different properties, such as bioavailability, which motivates the design of controlled processes to ensure consistent production of the desired polymorph to produce reliable therapeutic benefits upon delivery. The optimal batch control of the polymorphic transformation of L-glutamic acid from the metastable α-form to the stable β-form is studied, with the goal of optimizing batch productivity, while providing robustness to variations in the physicochemical parameters that can occur in practice due to variations in contaminant profiles in the feedstocks. A nonlinear state feedback controller designed to follow an optimal setpoint trajectory defined in the crystallization phase diagram simultaneously provided high-batch productivity and robustness, in contrast to optimal temperature control strategies that were either nonrobust or resulted in long-batch times. The results motivate the incorporation of the proposed approach into the design of operating procedures for polymorphic batch crystallizations. © 2007 American Institute of Chemical Engineers.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/aic.11266
dc.sourceScopus
dc.subjectC-control
dc.subjectPharmaceutical crystallization
dc.subjectPolymorphic transformation
dc.subjectRobust T-control
dc.subjectT-control
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1002/aic.11266
dc.description.sourcetitleAIChE Journal
dc.description.volume53
dc.description.issue10
dc.description.page2643-2650
dc.description.codenAICEA
dc.identifier.isiut000249756100013
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