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Title: Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering
Authors: Ee, L.A.
Zhao, H.
Obbard, J.P. 
Keywords: Biomolecular engineering
Directed evolution
Persistent organic pollutants
Issue Date: 3-Oct-2005
Citation: Ee, L.A., Zhao, H., Obbard, J.P. (2005-10-03). Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering. Enzyme and Microbial Technology 37 (5) : 487-496. ScholarBank@NUS Repository.
Abstract: With recent advances in biomolecular engineering, the bioremediation of persistent organic pollutants (POPs) using genetically modified microorganisms has become a rapidly growing area of research for environmental protection. Two main biomolecular approaches, rational design and directed evolution, have been developed to engineer enhanced microorganisms and enzymes for the biodegradation of POPs. This review describes the most recent developments and applications of these biomolecular tools for enhancing the capability of microorganisms to bioremediate three major classes of POPs - polycyclic aromatic hydrocabons (PAHs), polychlorinated biphenyls (PCBs) and pesticides. Most of the examples focused on the redesign of various features of the enzymes involved in the bioremediation of POPs, including the enzyme expression level, enzymatic activity and substrate specificity. Overall, the rapidly expanding potential of biomolecular engineering techniques has created the exciting potential of remediating some of the most recalcitrant and hazardous compounds in the environment. © 2005 Elsevier Inc. All rights reserved.
Source Title: Enzyme and Microbial Technology
ISSN: 01410229
DOI: 10.1016/j.enzmictec.2004.07.024
Appears in Collections:Staff Publications

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