Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201200814
Title: Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: Cellular uptake mechanism and two-photon fluorescence imaging
Authors: Geng, J.
Li, K.
Ding, D. 
Zhang, X.
Qin, W.
Liu, J.
Tang, B.Z.
Liu, B. 
Keywords: aggregation-induced emission
cellular uptake mechanism
fluorescence imaging
folic acid
two-photon absorption
Issue Date: 7-Dec-2012
Citation: Geng, J., Li, K., Ding, D., Zhang, X., Qin, W., Liu, J., Tang, B.Z., Liu, B. (2012-12-07). Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: Cellular uptake mechanism and two-photon fluorescence imaging. Small 8 (23) : 3655-3663. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201200814
Abstract: Folate functionalized nanoparticles (NPs) that contain fluorogens with aggregation-induced emission (AIE) characteristics are fabricated to show bright far-red/near-infrared fluorescence, a large two-photon absorption cross section and low cytotoxicity, which are internalized into MCF-7 cancer cells mainly through caveolae-mediated endocytosis. One-photon excited in vivo fluorescence imaging illustrates that these AIE NPs can accumulate in a tumor and two-photon excited ex vivo tumor tissue imaging reveals that they can be easily detected in the tumor mass at a depth of 400 μm. These studies indicate that AIE NPs are promising alternatives to conventional TPA probes for biological imaging. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
URI: http://scholarbank.nus.edu.sg/handle/10635/89334
ISSN: 16136810
DOI: 10.1002/smll.201200814
Appears in Collections:Staff Publications

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