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https://doi.org/10.1002/smll.201200814
| Title: | Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: Cellular uptake mechanism and two-photon fluorescence imaging | Authors: | Geng, J. Li, K. Ding, D. Zhang, X. Qin, W. Liu, J. Tang, B.Z. Liu, B. |
Keywords: | aggregation-induced emission cellular uptake mechanism fluorescence imaging folic acid two-photon absorption |
Issue Date: | 7-Dec-2012 | Citation: | Geng, J., Li, K., Ding, D., Zhang, X., Qin, W., Liu, J., Tang, B.Z., Liu, B. (2012-12-07). Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: Cellular uptake mechanism and two-photon fluorescence imaging. Small 8 (23) : 3655-3663. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201200814 | Abstract: | Folate functionalized nanoparticles (NPs) that contain fluorogens with aggregation-induced emission (AIE) characteristics are fabricated to show bright far-red/near-infrared fluorescence, a large two-photon absorption cross section and low cytotoxicity, which are internalized into MCF-7 cancer cells mainly through caveolae-mediated endocytosis. One-photon excited in vivo fluorescence imaging illustrates that these AIE NPs can accumulate in a tumor and two-photon excited ex vivo tumor tissue imaging reveals that they can be easily detected in the tumor mass at a depth of 400 μm. These studies indicate that AIE NPs are promising alternatives to conventional TPA probes for biological imaging. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Small | URI: | http://scholarbank.nus.edu.sg/handle/10635/89334 | ISSN: | 16136810 | DOI: | 10.1002/smll.201200814 |
| Appears in Collections: | Staff Publications |
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