Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2013.11.086
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dc.titleCo-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance
dc.contributor.authorZhu, H.
dc.contributor.authorChen, H.
dc.contributor.authorZeng, X.
dc.contributor.authorWang, Z.
dc.contributor.authorZhang, X.
dc.contributor.authorWu, Y.
dc.contributor.authorGao, Y.
dc.contributor.authorZhang, J.
dc.contributor.authorLiu, K.
dc.contributor.authorLiu, R.
dc.contributor.authorCai, L.
dc.contributor.authorMei, L.
dc.contributor.authorFeng, S.-S.
dc.date.accessioned2014-10-09T06:44:55Z
dc.date.available2014-10-09T06:44:55Z
dc.date.issued2014-02
dc.identifier.citationZhu, H., Chen, H., Zeng, X., Wang, Z., Zhang, X., Wu, Y., Gao, Y., Zhang, J., Liu, K., Liu, R., Cai, L., Mei, L., Feng, S.-S. (2014-02). Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance. Biomaterials 35 (7) : 2391-2400. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2013.11.086
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88666
dc.description.abstractWe report a strategy to make use of poly(lactic-co-glycolic acid) nanoparticle (PLGA NPs) for co-delivery of docetaxel (DTX) as a model anticancer drug together with vitamin E TPGS. The latter plays a dual role as a pore-forming agent in the nanoparticles that may result in smaller particle size, higher drug encapsulation efficiency and faster drug release, and also as a bioactive agent that could inhibit P-glycoprotein to overcome multi-drug resistance of the cancer cells, The DTX-loaded PLGA NPs of 0, 10, 20 and 40% TPGS were prepared by the nanoprecipitation method and then characterized for their size and size distribution, surface morphology, physical status and encapsulation efficiency of the drug in the NPs. All four NPs were found of size ranged 100-120nm and EE ranged 85-95% at drug loading level around 10%. The invitro evaluation showed that the 48h IC50 values of the free DTX and the DTX-loaded PLGA NPs of 0, 10, 20% TPGS were 2.619 and 0.474, 0.040, 0.009μg/mL respectively, which means that the PLGA NPs formulation could be 5.57 fold effective than the free DTX and that the DTX-loaded PLGA NPs of 10 or 20% TPGS further be 11.85 and 52.7 fold effective than the DTX-loaded PLGA NPs of no TPGS (therefore, 66.0 and 284 fold effective than the free DTX). Xenograft tumor model and immunohistological staining analysis further confirmed the advantages of the strategy of co-delivery of anticancer drugs with TPGS by PLGA NPs. © 2013 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2013.11.086
dc.sourceScopus
dc.subjectBiodegradable polymers
dc.subjectCancer nanotechnology
dc.subjectControlled release
dc.subjectMolecular biomaterial
dc.subjectNanomedicine
dc.subjectPharmaceutical nanotechnology
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.biomaterials.2013.11.086
dc.description.sourcetitleBiomaterials
dc.description.volume35
dc.description.issue7
dc.description.page2391-2400
dc.description.codenBIMAD
dc.identifier.isiut000331502300033
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