Please use this identifier to cite or link to this item:
|Title:||Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging||Authors:||Ding, D.
in vivo fluorescence imaging
in vivo toxicity
|Issue Date:||23-Sep-2013||Citation:||Ding, D., Liu, J., Feng, G., Li, K., Hu, Y., Liu, B. (2013-09-23). Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. Small 9 (18) : 3093-3102. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201300171||Abstract:||A highly emissive far-red/near-infrared (FR/NIR) fluorescent conjugated polymer (CP), poly[(9,9-dihexylfluorene)-co-2,1,3-benzothiadiazole-co-4,7- di(thiophen-2-yl)-2,1,3-benzothiadiazole] (PFBTDBT10) is designed and synthesized via Suzuki polymerization. Formulation of PFBTDBT10 using 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000) and DSPE-PEG5000-folate as the encapsulation matrix yielded CP-loaded DSPE-PEG-folic acid nanoparticles (CPDP-FA NPs) with bright FR/NIR fluorescence (27% quantum yield) and a large Stoke's shift of 233 nm in aqueous solution. CPDP-FA NPs show improved thermal/photostabilities and larger Stoke's shifts as compared to commercially available quantum dots (Qdot 655) and organic dyes such as Alexa Fluor 555 and Rhodamine 6G. In vivo studies of CPDP-FA NPs on a hepatoma H22 tumor-bearing mouse model reveal that they could serve as an efficient FR/NIR fluorescent probe for targeted in vivo fluorescence imaging and cancer detection in a high contrast and specific manner. Together with the negligible in vivo toxicity, CPDP-FA NPs are promising FR/NIR fluorescent probes for future in vivo applications. Bright far-red/near-infrared conjugated polymer nanoparticles with surface folate ligand and 27% quantum yield in aqueous media are synthesized via a one-step lipid-PEG-folate formulation. The obtained nanoparticles show good thermal/photostabilities and a large Stoke's shift, which compare favorably with commercially available quantum dots (Qdot 655) and organic dyes (Alexa Fluor 555 and Rhodamine 6G), making them a safe and efficient FR/NIR fluorescent probe for targeted in vivo fluorescence imaging and cancer detection in a high contrast and specific manner. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Source Title:||Small||URI:||http://scholarbank.nus.edu.sg/handle/10635/88595||ISSN:||16136810||DOI:||10.1002/smll.201300171|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 16, 2021
WEB OF SCIENCETM
checked on Jun 7, 2021
checked on Jun 8, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.