Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/88219
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dc.titleWall effects in continuous microfluidic magneto-affinity cell separation
dc.contributor.authorWu, L.
dc.contributor.authorZhang, Y.
dc.contributor.authorPalaniapan, M.
dc.contributor.authorRoy, P.
dc.date.accessioned2014-10-08T09:48:54Z
dc.date.available2014-10-08T09:48:54Z
dc.date.issued2010-05-01
dc.identifier.citationWu, L., Zhang, Y., Palaniapan, M., Roy, P. (2010-05-01). Wall effects in continuous microfluidic magneto-affinity cell separation. Biotechnology and Bioengineering 106 (1) : 68-75. ScholarBank@NUS Repository.
dc.identifier.issn00063592
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88219
dc.description.abstractContinuous microfluidic magneto-affinity cell separator combines unique microscale flow phenomenon with advantageous nanobead properties, to isolate cells with high specificity. Owing to the comparable size of the cell-bead complexes and the microchannels, the walls of the microchannel exert a strong influence on the separation of cells by this method. We present a theoretical and experimental study that provides a quantitative description of hydrodynamic wall interactions and wall rolling velocity of cells. A transient convection model describes the transport of cells in two-phase microfluidic flow under the influence of an external magnetic field. Transport of cells along the microchannel walls is also considered via an additional equation. Results show the variation of cell flux in the fluid phases and the wall as a function of a dimensionless parameter arising in the equations. Our results suggest that conditions may be optimized to maximize cell separation while minimizing contact with the wall surfaces. Experimentally measured cell rolling velocities on the wall indicate the presence of other near-wall forces in addition to fluid shear forces. Separation of a human colon carcinoma cell line from a mixture of red blood cells, with folic acid conjugated 1mm and 200nm beads, is reported. © 2010 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/bit.22665
dc.sourceScopus
dc.subjectCell separation
dc.subjectMagneto-affinity
dc.subjectMicrofluidic
dc.subjectWall effect
dc.typeArticle
dc.contributor.departmentELECTRICAL & COMPUTER ENGINEERING
dc.contributor.departmentBIOENGINEERING
dc.description.sourcetitleBiotechnology and Bioengineering
dc.description.volume106
dc.description.issue1
dc.description.page68-75
dc.description.codenBIBIA
dc.identifier.isiut000276844500007
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