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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jim.2004.09.016
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dc.titleSilole nanocrystals as novel biolabels
dc.contributor.authorChan, C.P.-Y.
dc.contributor.authorHaeussler, M.
dc.contributor.authorBen, Z.T.
dc.contributor.authorDong, Y.
dc.contributor.authorSin, K.-K.
dc.contributor.authorMak, W.-C.
dc.contributor.authorTrau, D.
dc.contributor.authorSeydack, M.
dc.contributor.authorRenneberg, R.
dc.date.accessioned2014-10-08T09:47:48Z
dc.date.available2014-10-08T09:47:48Z
dc.date.issued2004-12
dc.identifier.citationChan, C.P.-Y., Haeussler, M., Ben, Z.T., Dong, Y., Sin, K.-K., Mak, W.-C., Trau, D., Seydack, M., Renneberg, R. (2004-12). Silole nanocrystals as novel biolabels. Journal of Immunological Methods 295 (1-2) : 111-118. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jim.2004.09.016
dc.identifier.issn00221759
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88124
dc.description.abstractA novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were constructed by encapsulating nanocrystalline hexaphenylsilole [Ph 2Si(CPh)4; HPS] within ultrathin polyelectrolyte layers via the layer-by-layer (LbL) technique that provided an "interface" for the attachment of antibodies. A high ratio of fluorescent dyes to biomolecules (F/P ratio; 2.4×103) was achieved without self-quenching problem. The aggregation-induced emission (AIE) feature offered silole biolabels the sensitivity 40- to 140-fold higher than that of a start-of-the-art immunoassay using directly fluorescent-labeled antibodies. © 2004 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jim.2004.09.016
dc.sourceScopus
dc.subjectAggregation-induced emission (AIE)
dc.subjectBiolabel
dc.subjectFluorescence immunoassay (FIA)
dc.subjectLayer-by-layer (LbL) technique
dc.subjectSilole
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1016/j.jim.2004.09.016
dc.description.sourcetitleJournal of Immunological Methods
dc.description.volume295
dc.description.issue1-2
dc.description.page111-118
dc.description.codenJIMMB
dc.identifier.isiut000226392600011
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