Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.polymer.2004.01.021
DC FieldValue
dc.titlePreparation and characterization of inclusion complexes formed by biodegradable poly(ε-caprolactone)-poly(tetrahydrofuran)-poly(ε- caprolactone) triblock copolymer and cyclodextrins
dc.contributor.authorLi, J.
dc.contributor.authorChen, B.
dc.contributor.authorWang, X.
dc.contributor.authorGoh, S.H.
dc.date.accessioned2014-10-08T09:47:05Z
dc.date.available2014-10-08T09:47:05Z
dc.date.issued2004-03
dc.identifier.citationLi, J., Chen, B., Wang, X., Goh, S.H. (2004-03). Preparation and characterization of inclusion complexes formed by biodegradable poly(ε-caprolactone)-poly(tetrahydrofuran)-poly(ε- caprolactone) triblock copolymer and cyclodextrins. Polymer 45 (6) : 1777-1785. ScholarBank@NUS Repository. https://doi.org/10.1016/j.polymer.2004.01.021
dc.identifier.issn00323861
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88061
dc.description.abstractInclusion complexes (ICs) formed with cyclodextrins (CDs) and polymers have been an interesting topic over the past decade. Recently, more focus has been shifted to the ICs with biodegradable polymers or copolymers because of their potential applications as novel biomaterials. This work reports the IC formation between CDs and biodegradable poly(ε-caprolactone)- poly(tetrahydrofuran)-poly(ε-caprolactone) (PCL-PTHF-PCL) triblock copolymer and the characterization of the ICs. The PCL-PTHF-PCL triblock copolymer was found to form crystalline ICs with all α-, β-, and γ-CDs. All the three ICs were prepared in high yields from aqueous medium. The ICs were characterized by X-ray diffraction (XRD), 13C CP/MAS NMR, 1H NMR, Fourier transform infrared, differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). The XRD studies demonstrated that all the ICs assumed a channel-type structure similar to the necklace-like ICs formed by α-CD and poly(ethylene glycol) homopolymers. Solid-state CP/MAS 13C NMR studies showed that the CD molecules in the ICs adopted a symmetrical conformation due to the threading onto a polymer chain. The compositions of the ICs were studied by using 1H NMR spectroscopy. From the 1H NMR and DSC results, it was proposed that only the two flanking PCL blocks are included and covered by α-CD in the α-CD-PCL-PTHF-PCL IC, while the two PCL blocks as well as the middle PTHF block are included and covered by β-CD in the β-CD-PCL-PTHF-PCL IC. On the other hand, it was proposed that the PCL-PTHF-PCL copolymer is probably included and covered by γ-CD in a double-stranded mode in the γ-CD-PCL-PTHF-PCL IC. Finally, The TGA analysis revealed that the ICs had better thermal stability than their free components due to the inclusion complexation, suggesting that the complexation stabilized the copolymer included in the CD channels. © 2004 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.polymer.2004.01.021
dc.sourceScopus
dc.subjectCyclodextrin
dc.subjectInclusion complex
dc.subjectTriblock copolymer
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.polymer.2004.01.021
dc.description.sourcetitlePolymer
dc.description.volume45
dc.description.issue6
dc.description.page1777-1785
dc.description.codenPOLMA
dc.identifier.isiut000189214700007
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