Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bios.2012.02.050
DC FieldValue
dc.titleOptical diagnosis of laryngeal cancer using high wavenumber Raman spectroscopy
dc.contributor.authorLin, K.
dc.contributor.authorCheng, D.L.P.
dc.contributor.authorHuang, Z.
dc.date.accessioned2014-10-08T09:46:25Z
dc.date.available2014-10-08T09:46:25Z
dc.date.issued2012-05-15
dc.identifier.citationLin, K., Cheng, D.L.P., Huang, Z. (2012-05-15). Optical diagnosis of laryngeal cancer using high wavenumber Raman spectroscopy. Biosensors and Bioelectronics 35 (1) : 213-217. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bios.2012.02.050
dc.identifier.issn09565663
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88005
dc.description.abstractWe report the implementation of the transnasal image-guided high wavenumber (HW) Raman spectroscopy to differentiate tumor from normal laryngeal tissue at endoscopy. A rapid-acquisition Raman spectroscopy system coupled with a miniaturized fiber-optic Raman probe was utilized to realize real-time HW Raman (2800-3020cm -1) measurements in the larynx. A total of 94 HW Raman spectra (22 normal sites, 72 tumor sites) were acquired from 39 patients who underwent laryngoscopic screening. Significant differences in Raman intensities of prominent Raman bands at 2845, 2880 and 2920cm -1 (CH 2 stretching of lipids), and 2940cm -1 (CH 3 stretching of proteins) were observed between normal and cancer laryngeal tissue. The diagnostic algorithms based on principal components analysis (PCA) and linear discriminant analysis (LDA) together with the leave-one subject-out, cross-validation method on HW Raman spectra yielded a diagnostic sensitivity of 90.3% (65/72) and specificity of 90.9% (20/22) for laryngeal cancer identification. This study demonstrates that HW Raman spectroscopy has the potential for the noninvasive, real-time diagnosis and detection of laryngeal cancer at the molecular level. © 2012 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bios.2012.02.050
dc.sourceScopus
dc.subjectHigh wavenumber Raman spectroscopy
dc.subjectLaryngeal cancer
dc.subjectOptical diagnosis
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1016/j.bios.2012.02.050
dc.description.sourcetitleBiosensors and Bioelectronics
dc.description.volume35
dc.description.issue1
dc.description.page213-217
dc.description.codenBBIOE
dc.identifier.isiut000305036000032
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