Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-3-540-92841-6_562
DC FieldValue
dc.titleThree-dimensional Simulation of Blood Flow in Malaria Infection
dc.contributor.authorImai, Y.
dc.contributor.authorKondo, H.
dc.contributor.authorIshikawa, T.
dc.contributor.authorLim, C.T.
dc.contributor.authorTsubota, K.
dc.contributor.authorYamaguchi, T.
dc.date.accessioned2014-10-07T09:15:50Z
dc.date.available2014-10-07T09:15:50Z
dc.date.issued2009
dc.identifier.citationImai, Y.,Kondo, H.,Ishikawa, T.,Lim, C.T.,Tsubota, K.,Yamaguchi, T. (2009). Three-dimensional Simulation of Blood Flow in Malaria Infection. IFMBE Proceedings 23 : 2244-2247. ScholarBank@NUS Repository. <a href="https://doi.org/10.1007/978-3-540-92841-6_562" target="_blank">https://doi.org/10.1007/978-3-540-92841-6_562</a>
dc.identifier.isbn9783540928409
dc.identifier.issn16800737
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/86098
dc.description.abstractWe propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection. © 2009 International Federation of Medical and Biological Engineering.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/978-3-540-92841-6_562
dc.sourceScopus
dc.subjectcomputational fluid dynamics
dc.subjecthemodynamics
dc.subjectInfected red blood cell
dc.subjectnumerical modeling
dc.typeConference Paper
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1007/978-3-540-92841-6_562
dc.description.sourcetitleIFMBE Proceedings
dc.description.volume23
dc.description.page2244-2247
dc.identifier.isiutNOT_IN_WOS
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