Please use this identifier to cite or link to this item:
Title: Systematic fabrication of nano-carbonated hydroxyapatite/collagen composites for biomimetic bone grafts
Authors: Liao, S. 
Ngiam, M.
Watari, F.
Ramakrishna, S. 
Chan, C.K. 
Issue Date: 1-Sep-2007
Citation: Liao, S., Ngiam, M., Watari, F., Ramakrishna, S., Chan, C.K. (2007-09-01). Systematic fabrication of nano-carbonated hydroxyapatite/collagen composites for biomimetic bone grafts. Bioinspiration and Biomimetics 2 (3) : 37-41. ScholarBank@NUS Repository.
Abstract: A novel biomimetic self-assembly method was designed to create nano-carbonated hydroxyapatite/collagen (nCHAC) composites by means of incorporating various collagen and carbonate concentrations using solutions such as CaCl2, H3PO4, and Na2CO 3. At a given range of collagen and carbonate content, the nanosized inorganic phase of the newly synthesized material has a low degree of crystallinity which resembles that of natural bone. By manipulating the concentrations of collagen and carbonates, various morphologies of the nCHAC can be obtained. The crystal size of nCHAC is dependent on the concentration of carbonate and collagen present in the composites. For instance, higher collagen concentration results in smaller crystal nCHAC crystal size. Conversely, the higher the carbonate content, the smaller are the crystal size and the collagen fibril assembly. As the carbonate content increased, the plate-like crystals first became needle-like structures, subsequently short needle-like crystals and eventually became spherical particles. From this study, our method showcased the flexibility of fabricating various types of nCHAC composites which can be designed for different bone applications. © 2007 IOP Publishing Ltd.
Source Title: Bioinspiration and Biomimetics
ISSN: 17483182
DOI: 10.1088/1748-3182/2/3/001
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Feb 24, 2020


checked on Feb 24, 2020

Page view(s)

checked on Feb 16, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.