Please use this identifier to cite or link to this item:
DC FieldValue
dc.titleModeling of membrane potential dynamics induced by electromagnetic stimulation
dc.contributor.authorWu, T.
dc.contributor.authorJie, F.
dc.contributor.authorSeng, L.K.
dc.contributor.authorLi, X.
dc.contributor.authorWilder-Smith, E.P.V.
dc.identifier.citationWu, T.,Jie, F.,Seng, L.K.,Li, X.,Wilder-Smith, E.P.V. (2013). Modeling of membrane potential dynamics induced by electromagnetic stimulation. International IEEE/EMBS Conference on Neural Engineering, NER : 243-246. ScholarBank@NUS Repository. <a href="" target="_blank"></a>
dc.description.abstractTranscranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), and other electromagnetic stimulation modalities have been used to apply neuromodulation but their working mechanism remains largely unknown. This study aims to introduce a computer model for membrane potential dynamics induced by electromagnetic stimulation. In the simulation, realistic neuron morphologies are segmented into multiple compartments to calculate membrane potential changes numerically. This model is validated on multiple types of neocortical neurons. Membrane potential convergence and intracellular potential uniformity at steady state have been confirmed on neurons with insulating membrane. Minimum action potential firing thresholds measured under uniform field stimulation show that different types of neurons have distinct thresholds thus may have divergent responses when treated by neuromodulation. Simulated thresholds are compared with data obtained from in vitro experiment and no significant difference is observed. These results indicate that the simulation can successfully mimic neuron membrane dynamics induced by electromagnetic stimulation. © 2013 IEEE.
dc.typeConference Paper
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.sourcetitleInternational IEEE/EMBS Conference on Neural Engineering, NER
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.