Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-3-540-92841-6_374
DC FieldValue
dc.titleIn Vivo Study of ACL Regeneration Using Silk Scaffolds In a Pig Model
dc.contributor.authorLiu, H.
dc.contributor.authorFan, H.
dc.contributor.authorToh, S.L.
dc.contributor.authorGoh, J.C.H.
dc.date.accessioned2014-10-07T09:14:36Z
dc.date.available2014-10-07T09:14:36Z
dc.date.issued2009
dc.identifier.citationLiu, H.,Fan, H.,Toh, S.L.,Goh, J.C.H. (2009). In Vivo Study of ACL Regeneration Using Silk Scaffolds In a Pig Model. IFMBE Proceedings 23 : 1512-1514. ScholarBank@NUS Repository. <a href="https://doi.org/10.1007/978-3-540-92841-6_374" target="_blank">https://doi.org/10.1007/978-3-540-92841-6_374</a>
dc.identifier.isbn9783540928409
dc.identifier.issn16800737
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85992
dc.description.abstractAlthough most in vitro studies indicate that silk is a suitable biomaterial for ligament tissue engineering, in vivo studies of implanted silk scaffolds for ligament reconstruction are still lacking, especially in a big animal. The objective of this study is to investigate anterior cruciate ligament (ACL) regeneration using mesenchymal stem cells (MSCs) and silk scaffold in a pig model. The scaffold was fabricated by incorporating microporous silk sponges into knitted silk mesh, which mimicked the structures of ligament extracellular matrix (ECM). In vitro culture already demonstrated that MSCs on scaffolds proliferated vigorously and produced abundant collagen. The MSCs/scaffold was implanted to regenerate ACL in a pig model. After 24 weeks, histology observation showed that MSCs were distributed throughout the regenerated ligament and exhibited fibroblast morphology. The key ligament ECM components including collagen I, collagen III, and tenascin-C were produced prominently. The tensile strength of regenerated ligament also met the mechanical requirements. In conclusion, the results imply that silk scaffold has great potentials in future clinical applications.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/978-3-540-92841-6_374
dc.sourceScopus
dc.subjectACL
dc.subjectMSC
dc.subjectPig model
dc.subjectSilk scaffold
dc.typeConference Paper
dc.contributor.departmentORTHOPAEDIC SURGERY
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1007/978-3-540-92841-6_374
dc.description.sourcetitleIFMBE Proceedings
dc.description.volume23
dc.description.page1512-1514
dc.identifier.isiutNOT_IN_WOS
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