Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2013.01.040
DC FieldValue
dc.titleVitamin B12 loaded polycaprolactone nanofibers: A novel transdermal route for the water soluble energy supplement delivery
dc.contributor.authorMadhaiyan, K.
dc.contributor.authorSridhar, R.
dc.contributor.authorSundarrajan, S.
dc.contributor.authorVenugopal, J.R.
dc.contributor.authorRamakrishna, S.
dc.date.accessioned2014-10-07T09:12:43Z
dc.date.available2014-10-07T09:12:43Z
dc.date.issued2013-02-28
dc.identifier.citationMadhaiyan, K., Sridhar, R., Sundarrajan, S., Venugopal, J.R., Ramakrishna, S. (2013-02-28). Vitamin B12 loaded polycaprolactone nanofibers: A novel transdermal route for the water soluble energy supplement delivery. International Journal of Pharmaceutics 444 (1-2) : 70-76. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2013.01.040
dc.identifier.issn03785173
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85830
dc.description.abstractBiocompatible PCL polymer nanofiber mediated sustained release of hydrophilic drug and applicability as transdermal delivery system is attempted. This new attempt to investigate water soluble vitamin delivery with hydrophobic polymer nanofiber sustained the release of the vitamin and the method is suited for the transdermal patch applications. The drug loaded fibers were characterized with SEM for morphology, porometer for pore size measurements, mechanical strength calculation and FT-IR for drug load characterization. The contact angle measurement showed surface wettability and controlled release of drug was quantified with UV absorption measurements. To further enhance the release of vitamin, the polymer fiber was plasma treated at different time intervals and made hydrophilic gradually. Since the increased surface area and drug encapsulation in nano-reservoirs can able to release drug in small quantities and in a sustained manner we attempted the release of the energy supplement with nanofibrous delivery mode. © 2013 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ijpharm.2013.01.040
dc.sourceScopus
dc.subjectNanofiber
dc.subjectSustained release
dc.subjectTransdermal patch
dc.subjectVitamin B12
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentNUS NANOSCIENCE & NANOTECH INITIATIVE
dc.description.doi10.1016/j.ijpharm.2013.01.040
dc.description.sourcetitleInternational Journal of Pharmaceutics
dc.description.volume444
dc.description.issue1-2
dc.description.page70-76
dc.description.codenIJPHD
dc.identifier.isiut000315298700008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

63
checked on Dec 2, 2020

WEB OF SCIENCETM
Citations

64
checked on Dec 2, 2020

Page view(s)

77
checked on Nov 29, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.