Please use this identifier to cite or link to this item: https://doi.org/10.1088/1478-3975/10/3/036001
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dc.titleEffect of deformability difference between two erythrocytes on their aggregation
dc.contributor.authorJu, M.
dc.contributor.authorYe, S.S.
dc.contributor.authorLow, H.T.
dc.contributor.authorZhang, J.
dc.contributor.authorCabrales, P.
dc.contributor.authorLeo, H.L.
dc.contributor.authorKim, S.
dc.date.accessioned2014-10-07T09:03:21Z
dc.date.available2014-10-07T09:03:21Z
dc.date.issued2013-06
dc.identifier.citationJu, M., Ye, S.S., Low, H.T., Zhang, J., Cabrales, P., Leo, H.L., Kim, S. (2013-06). Effect of deformability difference between two erythrocytes on their aggregation. Physical Biology 10 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.1088/1478-3975/10/3/036001
dc.identifier.issn14783967
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85045
dc.description.abstractIn this study, we investigated the rheology of a doublet that is an aggregate of two red blood cells (RBCs). According to previous studies, most aggregates in blood flow consist of RBC doublet-pairs and thus the understanding of doublet dynamics has scientific importance in describing its hemodynamics. The RBC aggregation tendency can be significantly affected by the cell's deformability which can vary under both physiological and pathological conditions. Hence, we conducted a two-dimensional simulation of doublet dynamics under a simple shear flow condition with different deformability between RBCs. To study the dissociation process of the doublet, we employed the aggregation model described by the Morse-type potential function, which is based on the depletion theory. In addition, we developed a new method of updating fluid property to consider viscosity difference between RBC cytoplasm and plasma. Our results showed that deformability difference between the two RBCs could significantly reduce their aggregating tendency under a shear condition of 50 s-1, resulting in disaggregation. Since even under physiological conditions, the cell deformability may be significantly different, consideration of the difference in deformability amongst RBCs in blood flow would be needed for the hemodynamic studies based on a numerical approach. © 2013 IOP Publishing Ltd.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1088/1478-3975/10/3/036001
dc.description.sourcetitlePhysical Biology
dc.description.volume10
dc.description.issue3
dc.description.page-
dc.identifier.isiut000319863500012
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