Please use this identifier to cite or link to this item: https://doi.org/10.1163/156856204323046933
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dc.titleDevelopment of perforated microthin poly(E-caprolactone) films as matrices for membrane tissue engineering
dc.contributor.authorHtay, A.S.
dc.contributor.authorTeoh, S.H.
dc.contributor.authorHutmacher, D.W.
dc.date.accessioned2014-10-07T09:02:50Z
dc.date.available2014-10-07T09:02:50Z
dc.date.issued2004
dc.identifier.citationHtay, A.S., Teoh, S.H., Hutmacher, D.W. (2004). Development of perforated microthin poly(E-caprolactone) films as matrices for membrane tissue engineering. Journal of Biomaterials Science, Polymer Edition 15 (5) : 683-700. ScholarBank@NUS Repository. https://doi.org/10.1163/156856204323046933
dc.identifier.issn09205063
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85003
dc.description.abstractThe design and fabrication of thin films based on bioresorbable polymers such as poly(E-caprolactone) (PCL) has been the focus of a part of current biomedical research, especially as matrices for membrane tissue engineering. We have successfully developed perforated microthin PCL membrane for this purpose. Two critical issues are the control of moisture permeability and understanding the degradation of PCL microthin film. In order to increase the moisture permeability, PCL films were biaxially stretched to a thickness of 10 ± 3 μm and perforated with uniform array of holes (180-275 μm) using a Sony Robotic system. After perforation, the water vapour transmission rate was increased by 50% to a value of 47.6 ± 2.7 g/h per m2. Accelerated hydrolytic degradations were performed in 5 M NaOH. The degraded samples were characterised for changes in weight, surface morphology, mechanical properties, crystallinity and molecular weight. Hydrolytic degradation commenced with random chain scission of backbone ester bonds on the film surface and followed by loss of material due to surface erosion. In general, the perforated films degraded faster than the unperforated microthin films. Scanning electron microscopic images showed that surface erosion led to extensive formation of micropores, microcracks and increased in surface roughness. © VSP 2004.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1163/156856204323046933
dc.sourceScopus
dc.subjectAccelerated degradation
dc.subjectBiaxial stretching
dc.subjectPerforated film
dc.subjectPoly(E-caprolactone)
dc.subjectSodium hydroxide
dc.subjectTissue engineering
dc.subjectWater vapour transmission
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1163/156856204323046933
dc.description.sourcetitleJournal of Biomaterials Science, Polymer Edition
dc.description.volume15
dc.description.issue5
dc.description.page683-700
dc.description.codenJBSEE
dc.identifier.isiut000222280800011
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