Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bpj.2013.11.4459
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dc.titleQuantification of magnetically induced changes in ECM local apparent stiffness
dc.contributor.authorHerath, S.C.B.
dc.contributor.authorYue, D.
dc.contributor.authorHui, S.
dc.contributor.authorKim, M.-C.
dc.contributor.authorWang, D.-A.
dc.contributor.authorWang, Q.
dc.contributor.authorVan Vliet, K.J.
dc.contributor.authorAsada, H.
dc.contributor.authorChen, P.C.Y.
dc.date.accessioned2014-10-07T04:35:27Z
dc.date.available2014-10-07T04:35:27Z
dc.date.issued2014-01-07
dc.identifier.citationHerath, S.C.B., Yue, D., Hui, S., Kim, M.-C., Wang, D.-A., Wang, Q., Van Vliet, K.J., Asada, H., Chen, P.C.Y. (2014-01-07). Quantification of magnetically induced changes in ECM local apparent stiffness. Biophysical Journal 106 (1) : 332-341. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpj.2013.11.4459
dc.identifier.issn00063495
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/82951
dc.description.abstractThe stiffness of the extracellular matrix (ECM) is known to influence cell behavior. The ability to manipulate the stiffness of ECM has important implications in understanding how cells interact mechanically with their microenvironment. This article describes an approach to manipulating the stiffness ECM, whereby magnetic beads are embedded in the ECM through bioconjugation between the streptavidin-coated beads and the collagen fibers and then manipulated by an external magnetic field. It also reports both analytical results (obtained by formal modeling and numerical simulation) and statistically meaningful experimental results (obtained by atomic force microscopy) that demonstrate the effectiveness of this approach. These results clearly suggest the possibility of creating desired stiffness gradients in ECM in vitro to influence cell behavior. © 2014 by the Biophysical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bpj.2013.11.4459
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentELECTRICAL & COMPUTER ENGINEERING
dc.description.doi10.1016/j.bpj.2013.11.4459
dc.description.sourcetitleBiophysical Journal
dc.description.volume106
dc.description.issue1
dc.description.page332-341
dc.description.codenBIOJA
dc.identifier.isiut000329407700038
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