Please use this identifier to cite or link to this item: https://doi.org/10.1021/ac0302354
DC FieldValue
dc.titleTwo-Step Liquid-Liquid-Liquid Microextraction of Nonsteroidal Antiinflammatory Drugs in Wastewater
dc.contributor.authorWen, X.
dc.contributor.authorTu, C.
dc.contributor.authorLee, H.K.
dc.date.accessioned2014-06-23T05:53:42Z
dc.date.available2014-06-23T05:53:42Z
dc.date.issued2004-01-01
dc.identifier.citationWen, X., Tu, C., Lee, H.K. (2004-01-01). Two-Step Liquid-Liquid-Liquid Microextraction of Nonsteroidal Antiinflammatory Drugs in Wastewater. Analytical Chemistry 76 (1) : 228-232. ScholarBank@NUS Repository. https://doi.org/10.1021/ac0302354
dc.identifier.issn00032700
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77329
dc.description.abstractA simple and novel two-step liquid-liquid-liquid microextraction technique combined with reversed-phase HPLC has been developed for the determination of the nonsteroidal antiinflammatory drugs ibuprofen and 2-(4-chlorophenoxy)-2-methylpropionic acid in wastewater samples. In the first step, the analytes were extracted from an acidified sample (donor solution) into 1-octanol immobilized in the pores of 10 pieces of polypropylene hollow fiber and further into a basic acceptor phase inside the hollow fiber channels. This first extraction step, using 0.01 M NaOH as the acceptor phase and 0.1 M HCl within the donor phase, had a 100% relative recovery with an enrichment factor of 100-fold. The extract in the first step was then adjusted to acidic condition with HCl. It now represented the donor phase for the second step of the extraction, using a single piece of hollow fiber, with 2 μL of 0.01 M NaOH solution as the acceptor phase. This analyte-enriched acceptor phase was subsequently withdrawn into a microsyringe and directly injected into an HPLC system for analysis. With this two-step microextraction, sensitivity enhancement of > 15 000-fold could be obtained. Detection limits of ≤ 100 ng/L could be achieved for both compounds. The method was applied to the analysis of wastewater.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ac0302354
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/ac0302354
dc.description.sourcetitleAnalytical Chemistry
dc.description.volume76
dc.description.issue1
dc.description.page228-232
dc.description.codenANCHA
dc.identifier.isiut000187806100035
Appears in Collections:Staff Publications

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