Please use this identifier to cite or link to this item: https://doi.org/10.1021/cc900091e
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dc.titleTraceless solid-phase synthesis of 6-amino- and 6-hydroxyimino-1,3,5- triazine-2,4-diones and 1,3,5-triazine-2,4,6-triones
dc.contributor.authorKong, K.-H.
dc.contributor.authorTan, C.-K.
dc.contributor.authorLam, Y.
dc.date.accessioned2014-06-23T05:53:20Z
dc.date.available2014-06-23T05:53:20Z
dc.date.issued2009-11-09
dc.identifier.citationKong, K.-H., Tan, C.-K., Lam, Y. (2009-11-09). Traceless solid-phase synthesis of 6-amino- and 6-hydroxyimino-1,3,5- triazine-2,4-diones and 1,3,5-triazine-2,4,6-triones. Journal of Combinatorial Chemistry 11 (6) : 1050-1060. ScholarBank@NUS Repository. https://doi.org/10.1021/cc900091e
dc.identifier.issn15204766
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77301
dc.description.abstractA traceless solid-phase synthesis of 6-amino- and 6-hydroxyimino-1,3,5- triazine-2,4-diones and 1,3,5-triazine2,4,6-triones has been developed. The strategy comprises of linking a preformed N-carbamothioylcarbamate to bromomethyl resin to give a S-linked isothiourea, which then undergoes cyclization with isocynates to yield the resin-bound 1,3,5-triazine-2,4-diones. Subsequent cleavage was accomplished by either direct substitution with a suitable amine or by oxidative activation of the thioether functionality followed by nucleophilic substitution. Using this synthetic strategy, we prepared a representative set of 31 6-amino1,3,5-triazine-2,4-diones, 10 6-hydroxyimino-1,3,5-triazine-2,4-diones, and 8 1,3,5-triazine-2,4,6-triones. © 2009 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/cc900091e
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/cc900091e
dc.description.sourcetitleJournal of Combinatorial Chemistry
dc.description.volume11
dc.description.issue6
dc.description.page1050-1060
dc.description.codenJCCHF
dc.identifier.isiut000271428500013
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