Synthetic studies toward kaitocephalin

Abstract

Synthetic studies toward the total synthesis of kaitocephalin 1, whose stereochemical assignment was undetermined at the time of commencement, were undertaken in an attempt to provide a general methodology to gain access to any one of all 32 possible stereoisomers. An interesting, unexpected, result was observed in the anticipated stereoselective key aldol reaction. © 2001 Published by Elsevier Science Ltd.