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Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.200900964
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dc.titleSynthesis of a chiral quaternary carbon center bearing a fluorine atom: Enantio- and diastereoselective guanidine-catalyzed addition of fluorocarbon nucleophiles
dc.contributor.authorJiang, Z.
dc.contributor.authorPan, Y.
dc.contributor.authorZhao, Y.
dc.contributor.authorMa, T.
dc.contributor.authorLee, R.
dc.contributor.authorYang, Y.
dc.contributor.authorHuang, K.-W.
dc.contributor.authorWong, M.W.
dc.contributor.authorTan, C.-H.
dc.date.accessioned2014-06-23T05:51:45Z
dc.date.available2014-06-23T05:51:45Z
dc.date.issued2009-05-04
dc.identifier.citationJiang, Z., Pan, Y., Zhao, Y., Ma, T., Lee, R., Yang, Y., Huang, K.-W., Wong, M.W., Tan, C.-H. (2009-05-04). Synthesis of a chiral quaternary carbon center bearing a fluorine atom: Enantio- and diastereoselective guanidine-catalyzed addition of fluorocarbon nucleophiles. Angewandte Chemie - International Edition 48 (20) : 3627-3631. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200900964
dc.identifier.issn14337851
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77172
dc.description.abstractThe perfect combination: The title reaction provides adducts having quaternary carbon centers bearing a fluorine atom with high ee and d.r. values (see scheme). The mechanism and origin of stereoselectivity were elucidated by DFT calculations. The bifunctional mode of the guanidine catalysis was demonstrated in the transition states resulting from the DFT results. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.200900964
dc.sourceScopus
dc.subjectAsymmetric catalysis
dc.subjectFluorine
dc.subjectGuanidine
dc.subjectMichael addition
dc.subjectTransition states
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1002/anie.200900964
dc.description.sourcetitleAngewandte Chemie - International Edition
dc.description.volume48
dc.description.issue20
dc.description.page3627-3631
dc.description.codenACIEA
dc.identifier.isiut000266174200013
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