Please use this identifier to cite or link to this item:
https://doi.org/10.1016/0142-9612(95)00317-7
DC Field | Value | |
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dc.title | Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets | |
dc.contributor.author | Khor, E. | |
dc.contributor.author | Tay, L.F. | |
dc.contributor.author | Goh, K.S. | |
dc.contributor.author | Lee, C.N. | |
dc.date.accessioned | 2014-06-23T05:47:25Z | |
dc.date.available | 2014-06-23T05:47:25Z | |
dc.date.issued | 1996-08 | |
dc.identifier.citation | Khor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7 | |
dc.identifier.issn | 01429612 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/76816 | |
dc.description.abstract | A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0142-9612(95)00317-7 | |
dc.source | Scopus | |
dc.subject | Drug delivery | |
dc.subject | Endocarditis | |
dc.subject | Gentamicin | |
dc.subject | Prosthetic heart valves | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1016/0142-9612(95)00317-7 | |
dc.description.sourcetitle | Biomaterials | |
dc.description.volume | 17 | |
dc.description.issue | 16 | |
dc.description.page | 1631-1637 | |
dc.description.coden | BIMAD | |
dc.identifier.isiut | A1996VA40000012 | |
Appears in Collections: | Staff Publications |
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