Please use this identifier to cite or link to this item: https://doi.org/10.1016/0142-9612(95)00317-7
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dc.titlePrevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets
dc.contributor.authorKhor, E.
dc.contributor.authorTay, L.F.
dc.contributor.authorGoh, K.S.
dc.contributor.authorLee, C.N.
dc.date.accessioned2014-06-23T05:47:25Z
dc.date.available2014-06-23T05:47:25Z
dc.date.issued1996-08
dc.identifier.citationKhor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76816
dc.description.abstractA novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0142-9612(95)00317-7
dc.sourceScopus
dc.subjectDrug delivery
dc.subjectEndocarditis
dc.subjectGentamicin
dc.subjectProsthetic heart valves
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/0142-9612(95)00317-7
dc.description.sourcetitleBiomaterials
dc.description.volume17
dc.description.issue16
dc.description.page1631-1637
dc.description.codenBIMAD
dc.identifier.isiutA1996VA40000012
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