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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jorganchem.2005.08.041
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dc.titleOrganometallic cluster analogues of tamoxifen: Synthesis and biochemical assay
dc.contributor.authorChan, K.H.
dc.contributor.authorLeong, W.K.
dc.contributor.authorJaouen, G.
dc.contributor.authorLeclerq, L.
dc.contributor.authorTop, S.
dc.contributor.authorVessières, A.
dc.date.accessioned2014-06-23T05:46:04Z
dc.date.available2014-06-23T05:46:04Z
dc.date.issued2006-01-01
dc.identifier.citationChan, K.H., Leong, W.K., Jaouen, G., Leclerq, L., Top, S., Vessières, A. (2006-01-01). Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay. Journal of Organometallic Chemistry 691 (1-2) : 9-19. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jorganchem.2005.08.041
dc.identifier.issn0022328X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76704
dc.description.abstractSimple organometallic cluster analogues of tamoxifen containing triosmium or dicobalt carbonyl fragments have been prepared. Attempts at elaboration of these towards the tamoxifen skeleton were hampered by sensitivity of the cluster-ligand linkage towards the McMurry coupling conditions. Preliminary biological tests on various substrates indicate that the transition metal carbonyl fragment increases lipophilicity dramatically and reduces affinity for the estrogen receptor. © 2005 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jorganchem.2005.08.041
dc.sourceScopus
dc.subjectCluster
dc.subjectCobalt
dc.subjectOsmium
dc.subjectTamoxifen
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.jorganchem.2005.08.041
dc.description.sourcetitleJournal of Organometallic Chemistry
dc.description.volume691
dc.description.issue1-2
dc.description.page9-19
dc.description.codenJORCA
dc.identifier.isiut000234132900002
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