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https://doi.org/10.1021/ol2021274
DC Field | Value | |
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dc.title | Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: Facile access to chiral tertiary alcohols | |
dc.contributor.author | Liu, C. | |
dc.contributor.author | Dou, X. | |
dc.contributor.author | Lu, Y. | |
dc.date.accessioned | 2014-06-23T05:46:01Z | |
dc.date.available | 2014-06-23T05:46:01Z | |
dc.date.issued | 2011-10-07 | |
dc.identifier.citation | Liu, C., Dou, X., Lu, Y. (2011-10-07). Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: Facile access to chiral tertiary alcohols. Organic Letters 13 (19) : 5248-5251. ScholarBank@NUS Repository. https://doi.org/10.1021/ol2021274 | |
dc.identifier.issn | 15237060 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/76701 | |
dc.description.abstract | An efficient direct asymmetric aldol reaction between hydroxyacetone and β,γ-unsaturated α-keto esters has been successfully developed. In the presence of 9-amino-9-deoxy-epi-cinchonine and trifluoroacetic acid, the direct aldol reaction of O-protected hydroxyacetone proceeded in a highly enantioselective manner, affording the desired adducts containing a chiral tertiary alcohol in high yields and with excellent enantioselectivities. The aldol products obtained are valuable precursors for the synthesis of 2-substituted glycerol derivatives. © 2011 American ChemicalSociety. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ol2021274 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1021/ol2021274 | |
dc.description.sourcetitle | Organic Letters | |
dc.description.volume | 13 | |
dc.description.issue | 19 | |
dc.description.page | 5248-5251 | |
dc.identifier.isiut | 000295313900069 | |
Appears in Collections: | Staff Publications |
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