Please use this identifier to cite or link to this item:
https://doi.org/10.1055/s-2002-23142
DC Field | Value | |
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dc.title | Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone | |
dc.contributor.author | Wu, X. | |
dc.contributor.author | Cao, S. | |
dc.contributor.author | Goh, S. | |
dc.contributor.author | Hsu, A. | |
dc.contributor.author | Tan, B.K.H. | |
dc.date.accessioned | 2014-06-23T05:44:28Z | |
dc.date.available | 2014-06-23T05:44:28Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Wu, X., Cao, S., Goh, S., Hsu, A., Tan, B.K.H. (2002). Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone. Planta Medica 68 (3) : 198-203. ScholarBank@NUS Repository. https://doi.org/10.1055/s-2002-23142 | |
dc.identifier.issn | 00320943 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/76576 | |
dc.description.abstract | Gaudichaudione A, a cytotoxic xanthone obtained from Garcinia gaudichaudii, displayed strong growth inhibitory effects against Jurkat human leukemic cells, parental murine leukemic P388 and P388/DOX-resistant cell lines, and exhibited similar cytotoxicity against P388/DOX as well as P388, but was less toxic toward normal human Chang liver cells. A variety of apoptotic events induced by gaudichaudione A at the mitochondrial and nuclear levels has been characterized. It appears that gaudichaudione A induced a collapse of the mitochondrial transmembrane potential. Caspase-3 was activated and induced internucleosomal DNA fragmentation and externalization of PS residues. The apoptotic features were also observed in ultrastructural studies. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1055/s-2002-23142 | |
dc.source | Scopus | |
dc.subject | Annexin V | |
dc.subject | Apoptosis | |
dc.subject | Caspases | |
dc.subject | Flow cytometry | |
dc.subject | Gaudichaudione A | |
dc.subject | Mitochondrial transmembrane potential | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1055/s-2002-23142 | |
dc.description.sourcetitle | Planta Medica | |
dc.description.volume | 68 | |
dc.description.issue | 3 | |
dc.description.page | 198-203 | |
dc.description.coden | PLMEA | |
dc.identifier.isiut | 000174883700002 | |
Appears in Collections: | Staff Publications |
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