Please use this identifier to cite or link to this item: https://doi.org/10.1021/np9002838
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dc.titleLaetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia
dc.contributor.authorLear, M.J.
dc.contributor.authorSimon, O.
dc.contributor.authorFoley, T.L.
dc.contributor.authorBurkart, M.D.
dc.contributor.authorBaiga, T.J.
dc.contributor.authorNoel, J.P.
dc.contributor.authorDiPasquale, A.G.
dc.contributor.authorRheingold, A.L.
dc.contributor.authorLa Clair, J.J.
dc.date.accessioned2014-06-23T05:42:44Z
dc.date.available2014-06-23T05:42:44Z
dc.date.issued2009-11-30
dc.identifier.citationLear, M.J., Simon, O., Foley, T.L., Burkart, M.D., Baiga, T.J., Noel, J.P., DiPasquale, A.G., Rheingold, A.L., La Clair, J.J. (2009-11-30). Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. Journal of Natural Products 72 (11) : 1980-1987. ScholarBank@NUS Repository. https://doi.org/10.1021/np9002838
dc.identifier.issn01633864
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76432
dc.description.abstract(±)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of (±)-laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that (±)-laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis. © 2009 American Chemical Society and American Society of Pharmacognosy.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/np9002838
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/np9002838
dc.description.sourcetitleJournal of Natural Products
dc.description.volume72
dc.description.issue11
dc.description.page1980-1987
dc.description.codenJNPRD
dc.identifier.isiut000272227600012
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