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Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep02557
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dc.titleKinetic evidence of an apparent negative activation enthalpy in an organocatalytic process
dc.contributor.authorHan, X.
dc.contributor.authorLee, R.
dc.contributor.authorChen, T.
dc.contributor.authorLuo, J.
dc.contributor.authorLu, Y.
dc.contributor.authorHuang, K.-W.
dc.date.accessioned2014-06-23T05:42:36Z
dc.date.available2014-06-23T05:42:36Z
dc.date.issued2013
dc.identifier.citationHan, X., Lee, R., Chen, T., Luo, J., Lu, Y., Huang, K.-W. (2013). Kinetic evidence of an apparent negative activation enthalpy in an organocatalytic process. Scientific Reports 3 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/srep02557
dc.identifier.issn20452322
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76423
dc.description.abstractA combined kinetic and computational study on our tryptophan-based bifunctional thiourea catalyzed asymmetric Mannich reactions reveals an apparent negative activation enthalpy. The formation of the pre-transition state complex has been unambiguously confirmed and these observations provide an experimental support for the formation of multiple hydrogen bonding network between the substrates and the catalyst. Such interactions allow the creation of a binding cavity, a key factor to install high enantioselectivity.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/srep02557
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1038/srep02557
dc.description.sourcetitleScientific Reports
dc.description.volume3
dc.description.page-
dc.identifier.isiut000323696400011
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