Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/76415
Title: Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng
Authors: Chen, Z.-K. 
Fan, C.-X.
Ye, Y.-H.
Yang, L.
Jiang, Q.
Xing, Q.-Y.
Keywords: γ-glutamylarginine
Glutathione
N,N'-bis-γ- glutamylcystinylglycine
N-γ-glutamylcystinyl-bis-glycine
N-γ-glutamylglycylcysteine disulfide
Oligopeptide
Oxidized glutathione
Panax ginseng
Issue Date: 1998
Citation: Chen, Z.-K.,Fan, C.-X.,Ye, Y.-H.,Yang, L.,Jiang, Q.,Xing, Q.-Y. (1998). Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng. Journal of Peptide Research 52 (2) : 137-142. ScholarBank@NUS Repository.
Abstract: Six γ-glutamyl oligopeptides were isolated for the first time from aqueous methanol extracts of Panax ginseng root by using column chromatography on ion-exchange resin, gel filtration and reverse-phase high- performance liquid chromatography. Their structures had been established with the methods of amino acid analysis, N-terminal, C-terminal determination and double-coupling sequence analysis. They were: P-I (N-γ-glutamylcystinyl- bis-glycine), P-II (γ-glutamylcysteinylglycine disulfide, oxidized glutathione), P-III (N,N'-bis-γ-glutamylcystinylglycine), P-IV (γ- glutamylcysteinylglycinamide disulfide), P-V (N-γ-glutamylglycylcysteine disulfide), P-VI (γ-glutamylarginine); five of them are related to oxidized glutathione. The structures were further confirmed by the chemical synthesis. As far as we know, P-V (N-γ-glutamylglycylcysteine disulfide) is a new biologically active peptide which exhibits somnogenic effect and is more potent than that of P-II.
Source Title: Journal of Peptide Research
URI: http://scholarbank.nus.edu.sg/handle/10635/76415
ISSN: 1397002X
Appears in Collections:Staff Publications

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