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|Title:||Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng||Authors:||Chen, Z.-K.
|Issue Date:||1998||Citation:||Chen, Z.-K.,Fan, C.-X.,Ye, Y.-H.,Yang, L.,Jiang, Q.,Xing, Q.-Y. (1998). Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng. Journal of Peptide Research 52 (2) : 137-142. ScholarBank@NUS Repository.||Abstract:||Six γ-glutamyl oligopeptides were isolated for the first time from aqueous methanol extracts of Panax ginseng root by using column chromatography on ion-exchange resin, gel filtration and reverse-phase high- performance liquid chromatography. Their structures had been established with the methods of amino acid analysis, N-terminal, C-terminal determination and double-coupling sequence analysis. They were: P-I (N-γ-glutamylcystinyl- bis-glycine), P-II (γ-glutamylcysteinylglycine disulfide, oxidized glutathione), P-III (N,N'-bis-γ-glutamylcystinylglycine), P-IV (γ- glutamylcysteinylglycinamide disulfide), P-V (N-γ-glutamylglycylcysteine disulfide), P-VI (γ-glutamylarginine); five of them are related to oxidized glutathione. The structures were further confirmed by the chemical synthesis. As far as we know, P-V (N-γ-glutamylglycylcysteine disulfide) is a new biologically active peptide which exhibits somnogenic effect and is more potent than that of P-II.||Source Title:||Journal of Peptide Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/76415||ISSN:||1397002X|
|Appears in Collections:||Staff Publications|
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