Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2010.07.088
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dc.titleFine-tuning DNA/albumin polyelectrolyte interactions to produce the efficient transfection agent cBSA-147
dc.contributor.authorEisele, K.
dc.contributor.authorGropeanu, R.A.
dc.contributor.authorZehendner, C.M.
dc.contributor.authorRouhanipour, A.
dc.contributor.authorRamanathan, A.
dc.contributor.authorMihov, G.
dc.contributor.authorKoynov, K.
dc.contributor.authorKuhlmann, C.R.W.
dc.contributor.authorVasudevan, S.G.
dc.contributor.authorLuhmann, H.J.
dc.contributor.authorWeil, T.
dc.date.accessioned2014-06-23T05:39:33Z
dc.date.available2014-06-23T05:39:33Z
dc.date.issued2010-11
dc.identifier.citationEisele, K., Gropeanu, R.A., Zehendner, C.M., Rouhanipour, A., Ramanathan, A., Mihov, G., Koynov, K., Kuhlmann, C.R.W., Vasudevan, S.G., Luhmann, H.J., Weil, T. (2010-11). Fine-tuning DNA/albumin polyelectrolyte interactions to produce the efficient transfection agent cBSA-147. Biomaterials 31 (33) : 8789-8801. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2010.07.088
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76178
dc.description.abstractWe present the preparation and isolation of different chemically modified BSA species with varying numbers of primary amino groups at the surface. Highly cationic albumin proteins with increased numbers of amino groups were achieved and complex formation with plasmid DNA was carefully investigated. We compare the transfection results, polyelectrolyte complexes morphologies with their impact on complex stabilities, cytotoxicities and DNA accessibility. This knowledge-driven approach led to the identification of the efficient non-viral DNA delivery agent cBSA-147, which showed high transfection efficacies and stability. © 2010 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2010.07.088
dc.sourceScopus
dc.subjectCationized serum albumin
dc.subjectCBSA-147
dc.subjectIsothermal titration calorimetry
dc.subjectPolyelectrolyte complex formation
dc.subjectProtein transfection agent
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.biomaterials.2010.07.088
dc.description.sourcetitleBiomaterials
dc.description.volume31
dc.description.issue33
dc.description.page8789-8801
dc.description.codenBIMAD
dc.identifier.isiut000283912700031
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