Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0960-894X(03)00633-4
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dc.titleCombinatorial peptide microarrays for the rapid determination of kinase specificity
dc.contributor.authorUttamchandani, M.
dc.contributor.authorChan, E.W.S.
dc.contributor.authorChen, G.Y.J.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-06-23T05:34:29Z
dc.date.available2014-06-23T05:34:29Z
dc.date.issued2003-09
dc.identifier.citationUttamchandani, M., Chan, E.W.S., Chen, G.Y.J., Yao, S.Q. (2003-09). Combinatorial peptide microarrays for the rapid determination of kinase specificity. Bioorganic and Medicinal Chemistry Letters 13 (18) : 2997-3000. ScholarBank@NUS Repository. https://doi.org/10.1016/S0960-894X(03)00633-4
dc.identifier.issn0960894X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/75774
dc.description.abstractWe report a rapid method for profiling of kinases using a strategy that couples the merits of combinatorics (in rapid diversity generation) with the throughput attainable using microarrays (in parallel screening). Alanine-scanning, deletion and positional-scanning peptide libraries of a kinase substrate were synthesized and site-specifically arrayed onto glass slides. The phosphorylation pattern of target sequences detected using fluorescently-labeled antiphosphoamino acid antibodies revealed the substrate preference of the kinase through its activity profile. © 2003 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0960-894X(03)00633-4
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/S0960-894X(03)00633-4
dc.description.sourcetitleBioorganic and Medicinal Chemistry Letters
dc.description.volume13
dc.description.issue18
dc.description.page2997-3000
dc.description.codenBMCLE
dc.identifier.isiut000185221400011
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