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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2005.11.133
DC FieldValue
dc.titleChiral bicyclic guanidines: A concise and efficient aziridine-based synthesis
dc.contributor.authorYe, W.
dc.contributor.authorLeow, D.
dc.contributor.authorGoh, S.L.M.
dc.contributor.authorTan, C.-T.
dc.contributor.authorChian, C.-H.
dc.contributor.authorTan, C.-H.
dc.date.accessioned2014-06-23T05:34:09Z
dc.date.available2014-06-23T05:34:09Z
dc.date.issued2006-02-06
dc.identifier.citationYe, W., Leow, D., Goh, S.L.M., Tan, C.-T., Chian, C.-H., Tan, C.-H. (2006-02-06). Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis. Tetrahedron Letters 47 (6) : 1007-1010. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2005.11.133
dc.identifier.issn00404039
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/75746
dc.description.abstractA series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only three requiring chromatographic purification, giving the desired guanidines in 43-71% overall yield. Preliminary studies using these guanidines showed moderate enantioselectivity for several Michael reactions. © 2005 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.tetlet.2005.11.133
dc.sourceScopus
dc.subjectAziridine
dc.subjectEnantioselectivity
dc.subjectGuanidine
dc.subjectMichael reaction
dc.subjectRegioselectivity
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.tetlet.2005.11.133
dc.description.sourcetitleTetrahedron Letters
dc.description.volume47
dc.description.issue6
dc.description.page1007-1010
dc.description.codenTELEA
dc.identifier.isiut000234953300036
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