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Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.200903635
DC FieldValue
dc.titleAsymmetric mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst
dc.contributor.authorHan, X.
dc.contributor.authorKwiatkowski, J.
dc.contributor.authorXue, T.
dc.contributor.authorHuang, K.-W.
dc.contributor.authorLu, Y.
dc.date.accessioned2014-06-23T05:32:35Z
dc.date.available2014-06-23T05:32:35Z
dc.date.issued2009-09-28
dc.identifier.citationHan, X., Kwiatkowski, J., Xue, T., Huang, K.-W., Lu, Y. (2009-09-28). Asymmetric mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst. Angewandte Chemie - International Edition 48 (41) : 7604-7607. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903635
dc.identifier.issn14337851
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/75620
dc.description.abstractFluorinated quaternary stereocenters: A novel bifunctional catalyst 1 derived from natural tryptophan promoted the Mannich reaction of α-fluoro-β-ketoesters to afford fluorinated chiral molecules containing vicinal quaternary and tertiary stereogenic centers with exceptional enantioselectivity. An unprecedented α-fluoro-β -lactam was also prepared by this method (see scheme; Boc=tert-butoxycarbonyl). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.200903635
dc.sourceScopus
dc.subjectAsymmetric synthesis
dc.subjectFluorination
dc.subjectMannich reaction
dc.subjectOrganocatalysis
dc.subjectQuaternary stereocenters
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1002/anie.200903635
dc.description.sourcetitleAngewandte Chemie - International Edition
dc.description.volume48
dc.description.issue41
dc.description.page7604-7607
dc.description.codenACIEA
dc.identifier.isiut000270436900023
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