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Title: Saliva-based diagnostics using 16S rRNA microarrays and microfluidics
Authors: Starke, E.M.
Smoot, J.C.
Wu, J.-H. 
Liu, W.-T. 
Chandler, D.
Stahl, D.A.
Keywords: Microarrays
Microbial ecology
Issue Date: Mar-2007
Citation: Starke, E.M., Smoot, J.C., Wu, J.-H., Liu, W.-T., Chandler, D., Stahl, D.A. (2007-03). Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Annals of the New York Academy of Sciences 1098 : 345-361. ScholarBank@NUS Repository.
Abstract: The development of a diagnostic system based on DNA microarrays for rapid identification and enumeration of microbial species in the oral cavity is described. This system uses gel-based microarrays with immobilized probes designed within a phylogenetic framework that provides for comprehensive microbial monitoring. Understanding the community structure in the oral cavity is a necessary foundation onwhich to understand the breadth and depth of different microbial communities in the oral cavity and their role in acute and systemic disease. Our ultimate goal is to develop a diagnostic device to identify individuals at high risk for oral disease, and thereby reduce its prevalence and therefore the economic burden associated with treatment. This article discusses recent improvements of our system in reducing diffusional constraints in order to provide more rapid and accurate measurements of the microbial composition of saliva. © 2007 New York Academy of Sciences.
Source Title: Annals of the New York Academy of Sciences
ISBN: 157331661X
ISSN: 00778923
DOI: 10.1196/annals.1384.007
Appears in Collections:Staff Publications

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