Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/74913
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dc.titlePathological diagnosis of bladder cancer by image analysis of hypericin induced fluorescence cystoscopic images
dc.contributor.authorKah, J.C.Y.
dc.contributor.authorOlivo, M.C.
dc.contributor.authorLau, W.K.O.
dc.contributor.authorSheppard, C.J.R.
dc.date.accessioned2014-06-19T08:58:57Z
dc.date.available2014-06-19T08:58:57Z
dc.date.issued2005
dc.identifier.citationKah, J.C.Y.,Olivo, M.C.,Lau, W.K.O.,Sheppard, C.J.R. (2005). Pathological diagnosis of bladder cancer by image analysis of hypericin induced fluorescence cystoscopic images. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5863 : 1-8. ScholarBank@NUS Repository.
dc.identifier.issn16057422
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/74913
dc.description.abstractPhotodynamic diagnosis of bladder carcinoma based on hypericin fluorescence cystoscopy has shown to have a higher degree of sensitivity for the detection of flat bladder carcinoma compared to white light cystoscopy. The potential of the photosensitizer hypericin-induced fluorescence in performing non-invasive optical biopsy to grade bladder cancer in vivo using fluorescence cystoscopic image analysis without surgical resection for tissue biopsy is investigated in this study. The correlation between tissue fluorescence and histopathology of diseased tissue was explored and a diagnostic algorithm based on fluorescence image analysis was developed to classify the bladder cancer without surgical resection for tissue biopsy. Preliminary results suggest a correlation between tissue fluorescence and bladder cancer grade. By combining both the red-to-blue and red-to-green intensity ratios into a 20 scatter plot yields an average sensitivity and specificity of around 70% and 85% respectively for pathological cancer grading of the three different grades of bladder cancer. Therefore, the diagnostic algorithm based on colorimetric intensity ratio analysis of hypericin fluorescence cystoscopic images developed in this preliminary study shows promising potential to optically diagnose and grade bladder cancer in vivo. © 2005 SPIE and OSA.
dc.sourceScopus
dc.subjectBladder cancer
dc.subjectCancer diagnosis
dc.subjectDigitized fluorescence endoscopy imaging
dc.subjectFluorescence cystoscopy
dc.subjectFluorescence quantification
dc.subjectHypericin
dc.subjectImage analysis
dc.subjectOptical biopsy
dc.subjectPhotodynamic diagnosis
dc.typeConference Paper
dc.contributor.departmentBIOENGINEERING
dc.description.sourcetitleProgress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.description.volume5863
dc.description.page1-8
dc.identifier.isiutNOT_IN_WOS
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