Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/73240
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dc.titleCell cycle synchronization of stem cells using inertial microfluidics
dc.contributor.authorLee, W.C.
dc.contributor.authorBhagat, A.A.S.
dc.contributor.authorHuang, S.
dc.contributor.authorVan Vliet, K.J.
dc.contributor.authorHan, J.
dc.contributor.authorLim, C.T.
dc.date.accessioned2014-06-19T05:32:47Z
dc.date.available2014-06-19T05:32:47Z
dc.date.issued2010
dc.identifier.citationLee, W.C.,Bhagat, A.A.S.,Huang, S.,Van Vliet, K.J.,Han, J.,Lim, C.T. (2010). Cell cycle synchronization of stem cells using inertial microfluidics. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 1 : 208-210. ScholarBank@NUS Repository.
dc.identifier.isbn9781618390622
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/73240
dc.description.abstractCell cycle synchronization is of paramount importance for studying cellular properties and biological processes involved in various stages of the cell cycle. Here, we present a microfluidics based approach to synchronize the cell cycle of a primary - cells, human bone marrow-derived mesenchymal stem cells (hMSCs), using inertial forces in spiral microchan-nels. The device operating principle exploits the relationship between the volume (and thus diameter) of a cell and its phase in the cell cycle, in order to fractionate hMSCs populations into synchronized subpopulations enriched in cell cycle fractions of G0/G1, S and G2/M phases.
dc.sourceScopus
dc.subjectCell cycle
dc.subjectDean flows
dc.subjectInertial forces
dc.subjectSize fractionation
dc.subjectStem cells
dc.typeConference Paper
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.sourcetitle14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
dc.description.volume1
dc.description.page208-210
dc.identifier.isiutNOT_IN_WOS
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