An in vivo evaluation of a bioactive composite matrix for dermal regeneration

Abstract

An in vitro study to examine cell attachment and proliferation was carried out using human dermal fibroblasts on the PLGA-collagen hybrid mesh. Cell attachment, morphology, and viability were analyzed using scanning electron microscopy (SEM), light microscopy and confocal laser microscopy. It was observed that a composite matrix was made by freeze-drying collagen, within a PLGA knitted mesh in order to circumvent some of the disadvantages of each group of materials. The results show that meshes were capable of supporting cell attachment, proliferation and neotissue formation.