p53-Mdm2 core regulation revealed by a mathematical model

Please use this identifier to cite or link to this item: https://doi.org/10.1109/ICSMC.2008.4811537

Title:	p53-Mdm2 core regulation revealed by a mathematical model
Authors:	Yang, Y. Lin, H.
Keywords:	Bifurcation analysis Mathematical model p53-Mdm2 core regulation Systems biology
Issue Date:	2008
Citation:	Yang, Y.,Lin, H. (2008). p53-Mdm2 core regulation revealed by a mathematical model. Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics : 1725-1730. ScholarBank@NUS Repository. https://doi.org/10.1109/ICSMC.2008.4811537
Abstract:	p53 is a paramount protein in cancer studies. p53-Mdm2 interaction is the core regulation for most activities of p53 protein-related networks. In this paper a new mathematical model is proposed to reveal the mechanisms existing in this core regulation. This model is mainly based on the recent biological findings, as well as few reasonable hypotheses and approximations. The performance is in good accord with the experimental phenomenon in the literature. And a new threshold mechanism is also discussed, which gives more insights for experimental design and validation. © 2008 IEEE.
Source Title:	Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
URI:	http://scholarbank.nus.edu.sg/handle/10635/71354
ISSN:	1062922X
DOI:	10.1109/ICSMC.2008.4811537
Appears in Collections:	Staff Publications

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